Vitamin A and systemic inflammation as protective factors in multiple sclerosis
Vitamin A and systemic inflammation as protective factors in multiple sclerosis
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DOI：
10.1177/1352458512472752
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发表时间：
2013-07-01
影响因子：
5.8
通讯作者：
Sundstrom, Peter
中科院分区：
文献类型：
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作者：
Salzer, Jonatan;Hallmans, Goran;Sundstrom, Peter
背景资料：维生素A对免疫系统很重要，并且可能抑制多发性硬化症（MS）的炎症活动。目的：我们的目的是检查在前瞻性和妊娠期间收集的样本中维生素A水平是否与MS风险相关。方法：我们测量了视黄醇结合蛋白（RBP -维生素A的替代标志物）和高敏C反应蛋白（hs-CRP）水平，在（1）从MS病例和对照中前瞻性地收集生物库血液样品，和（2）后代后来发展MS的妊娠样品，和妊娠对照样品中。MS的风险计算使用匹配的多变量logistic回归调整confersider.Results：在前瞻性样本中，RBP水平在第二个五分位数（与第一）与MS风险较低（OR = 0.38，95%CI 0.19-0.74）。妊娠期RBP水平对后代MS风险无影响。在年轻受试者中，hs-CRP水平10 mg/l的前瞻性样本与较低的MS风险相关（OR = 0.36，95%CI 0.14-0.95）。年轻受试者中hs-CRP水平与MS风险之间的关联可能支持卫生假说在MS病因学中的作用。
Background: Vitamin A is important for the immune system, and might suppress inflammatory activity in multiple sclerosis (MS).Objectives: We aimed to examine if vitamin A levels were associated with MS risk in samples collected prospectively and during gestation.Methods: We measured Retinol Binding Protein (RBP - a surrogate marker for vitamin A) and high-sensitivity C-reactive protein (hs-CRP) levels, in (1) prospectively collected biobank blood samples from MS cases and controls, and (2) gestational samples where the offspring had later developed MS, and gestational control samples. The risk of MS was calculated using matched multivariable logistic regression adjusted for confounders.Results: In prospective samples, RBP levels within the second quintile (vs. the first) were associated with a lower MS risk (OR = 0.38, 95% CI 0.19-0.74). No effect on MS risk in the offspring by gestational RBP levels was found. In young subjects hs-CRP levels 10 mg/l in prospective samples were associated with a lower MS risk (OR = 0.36, 95% CI 0.14-0.95).Conclusions: Our results suggest that sub-optimal vitamin A levels may be associated with MS risk. The association between hs-CRP levels and MS risk in young subjects may support the role of the hygiene hypothesis in MS aetiology.