Architecture and connections of retrosplenial area 30 in the rhesus monkey (macaca mulatta).
Architecture and connections of retrosplenial area 30 in the rhesus monkey (macaca mulatta).
复制标题
DOI：
10.1046/j.1460-9568.1999.00672.x
复制
发表时间：
1999-07-01
影响因子：
3.4
通讯作者：
Pandya, DN
中科院分区：
文献类型：
--
作者：
Morris, R;Petrides, M;Pandya, DN
由于胼胝体压部周围脾后区域的尖锐弯曲，标准的冠状切片不适合对其腹后部进行建筑学分析。在本研究中，对恒河猴脾后腹侧脾后区的检查，在与其曲率轴垂直的切片上(因此适合于建筑学分析)，可以定义其结构和精确的范围。这一分析表明，脾后皮质的29区和30区，以及邻近的后扣带皮质区23区，在整个过程中都像拱形一样围绕胼胝体压部延伸，并保持着彼此的地形关系。在脾后30区注射顺行和逆行示踪剂，发现该区域与邻近的23区、19区和PGM区有相互联系，与前额叶皮质的背中外侧区(9区、9/46区和46区)有相互联系，在颞叶上沟有多峰区TPO，以及海马后副皮质、小脑丘前和内嗅皮层。与丘脑后外侧核、背外侧核和丘脑前腹侧边缘核也有双向联系。30区的连通性表明，它可能在工作记忆过程中发挥作用，工作记忆过程由额叶中背外侧皮质与海马体系统相互作用提供支持。
Because of the sharp curvature of the retrosplenial region around the splenium of the corpus callosum, standard coronal sections are not appropriate for architectonic analysis of its posteroventral part. In the present study, examination of the posteroventral retrosplenial region of the rhesus monkey in sections that were orthogonal to its axis of curvature (and therefore appropriate for architectonic analysis) has permitted definition of its architecture and precise extent. This analysis demonstrated that areas 29 and 30 of the retrosplenial cortex, as well as adjacent area 23 of the posterior cingulate cortex, extend together as an arch around the splenium of the corpus callosum and maintain their topographical relationship with one another throughout their entire course. Injections of anterograde and retrograde tracers confined to retrosplenial area 30 revealed that this area has reciprocal connections with adjacent areas 23, 19 and PGm, with the mid-dorsolateral part of the prefrontal cortex (areas 9, 9/46 and 46), with multimodal area TPO in the superior temporal sulcus, as well as the posterior parahippocampal cortex, the presubiculum and the entorhinal cortex. There are also bidirectional connections with the lateroposterior thalamic nucleus, as well as the laterodorsal and the anteroventral limbic thalamic nuclei. The connectivity of area 30 suggests that it may play a role in working memory processes subserved by the mid-dorsolateral frontal cortex in interaction with the hippocampal system.