Synthesis and antimicrobial properties of polymerizable quaternary ammoniums
Synthesis and antimicrobial properties of polymerizable quaternary ammoniums
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DOI：
10.1016/j.ejmech.2009.03.031
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发表时间：
2009-08-01
影响因子：
6.7
通讯作者：
Guittard, Frederic
中科院分区：
文献类型：
--
作者：
Caillier, Laurent;de Givenchy, Elisabeth Taffin;Guittard, Frederic
在聚合过程中引入杀生剂单体是开发新型永久性不浸出杀生剂材料的一条很有前途的途径。合成了以季铵盐基为极性头，以丙烯酸官能团为可聚合基团的两个系列表面活性剂单体，并对它们的表面活性以及抗菌、抗真菌性能进行了测试。以铜绿假单胞菌、金黄色葡萄球菌为研究对象。白色念珠菌和黑曲霉。以最小抑菌浓度和最小致死浓度作为分子参数的函数，讨论了以细菌和真菌生长抑制来衡量的生物杀灭效果。所有合成的表面活性单体都具有杀菌和杀菌活性。增加丙烯酸部分和氨基之间的间隔基对MIC和MLC结果有有利的影响。(C)2009年爱思唯尔·马森公司。版权所有。
Introduction of biocide monomers during the process of polymerization is a promising approach in the development of new permanent non leaching biocide materials. Two series of surfactants monomers, with a quaternary ammonium group as polar head and an acrylic function as the polymerizable moiety, were synthesized and tested to evaluate their surface active properties alongside with their antibacterial and antifungal properties. Four microbial strains were used to perform the study: Pseudomonas aeruginosa, Staphylococcus aureus. Candida albicans and Aspergillus niger. The biocidal efficacy measured by bacterial and fungal growth inhibition expressed as MIC (Minimal Inhibitory Concentration) and MLC (Minimal Lethal Concentration) values was discussed as a function of molecular parameters. All the synthesized surfactant monomers presented bactericidal and fungicidal activities. Increasing the spacer between the acrylic part and the ammonium group has a favourable effect on the MIC and MLC results. (C) 2009 Elsevier Masson SAS. All rights reserved.