Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes
Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes
复制标题
DOI：
10.1210/jc.2005-1231
复制
发表时间：
2006-03-01
影响因子：
5.8
通讯作者：
Torp-Pedersen, C
中科院分区：
文献类型：
--
作者：
Hermann, TS;Li, WJ;Torp-Pedersen, C
目的：血管紧张素转换酶抑制剂可降低2型糖尿病患者的心血管死亡率并改善血管内皮功能。我们假设，2个月的喹那普利治疗将改善胰岛素刺激的内皮功能和葡萄糖摄取在2型糖尿病患者，同时增加相关的内皮功能和metabolis.Methods的基因的表达：24型糖尿病患者随机接受2个月的喹那普利20毫克，每天或没有治疗在一个开放的平行研究。本文研究了糖尿病患者和15名健康人在静脉输注5-羟色胺或硝普钠时的内皮依赖性和非依赖性血管舒张作用。内皮功能，胰岛素刺激的内皮功能，胰岛素刺激的葡萄糖摄取在喹那普利治疗前后进行了测量。通过静脉闭塞体积描记术测量血流量。基因表达测定通过real-timePCR.Results：喹那普利治疗增加胰岛素刺激的2型糖尿病患者的内皮功能（P = 0.005），而前臂葡萄糖摄取量不变。内皮功能也增加了喹那普利（P = 0.001）。喹那普利可降低收缩压和舒张压（P < 0.001）。喹那普利增加脂联素基因表达血管组织获得皮下脂肪biopsizes.Conclusions：喹那普利治疗增加胰岛素刺激的2型糖尿病患者的内皮功能。增加血管脂联素基因表达可能有助于这种有益的效果。
Objective: Angiotensin-converting enzyme inhibitors reduce cardiovascular mortality and improve endothelial function in type 2 diabetic patients. We hypothesized that 2 months of quinapril treatment would improve insulin-stimulated endothelial function and glucose uptake in type 2 diabetic subjects and simultaneously increase the expression of genes that are pertinent for endothelial function and metabolism.Methods: Twenty-four type 2 diabetic subjects were randomized to receive 2 months of quinapril 20 mg daily or no treatment in an open parallel study. Endothelium-dependent and -independent vasodilation was studied during serotonin or sodium nitroprusside infusion in the diabetic patients and in 15 healthy subjects. Endothelial function, insulin-stimulated endothelial function, and insulin-stimulated glucose uptake were measured before and after quinapril treatment. Blood flow was measured by venous occlusion plethysmography. Gene expression was measured by real-time PCR.Results: Quinapril treatment increased insulin-stimulated endothelial function in the type 2 diabetic subjects (P = 0.005), whereas forearm glucose uptake was unchanged. Endothelial function was also increased by quinapril (P = 0.001). Systolic and diastolic blood pressures were reduced by quinapril (P < 0.001). Quinapril increased adiponectin gene expression in vascular tissue obtained from sc adipose biopsies.Conclusions: Quinapril treatment increases insulin-stimulated endothelial function in patients with type 2 diabetes. Increased vascular adiponectin gene expression may contribute to this beneficial effect.