Reactivation of latent working memories with transcranial magnetic stimulation.
Reactivation of latent working memories with transcranial magnetic stimulation.
复制标题
通过经颅磁刺激的潜在工作记忆重新激活。
DOI：
10.1126/science.aah7011
复制
发表时间：
2016-12-02
期刊：
影响因子：
--
通讯作者：
Postle BR
中科院分区：
文献类型：
--
作者：
Rose NS;LaRocque JJ;Riggall AC;Gosseries O;Starrett MJ;Meyering EE;Postle BR
在工作记忆（WM）中保持信息的能力是认知的基础。与长期以来认为WM依赖于持续的、升高的活动的观点相反，我们提出的证据表明，信息可以通过“活动沉默”的突触机制在WM中保持。使用机器学习来解码大脑活动模式，我们发现当注意力转移时，WM中项目的主动表示会下降到基线。经颅磁刺激的目标脉冲在同时测量的大脑活动中产生该项目的短暂重现。这种再激活效应只会在项目在试验后期可能相关时才会发生并影响记忆表现，这表明表征是动态的，可以通过认知控制进行修改。研究结果支持工作记忆的突触理论。
The ability to hold information in working memory (WM) is fundamental for cognition. Contrary to the longstanding view that WM depends on sustained, elevated activity, we present evidence suggesting that information can be held in WM via “activity-silent” synaptic mechanisms. Using machine learning to decode brain activity patterns, we show that the active representation of an item in WM drops to baseline when attention shifts away. A targeted pulse of transcranial magnetic stimulation produces a brief reemergence of the item in concurrently measured brain activity. This reactivation effect only occurs and influences memory performance when the item is potentially relevant later in the trial, suggesting that the representation is dynamic and modifiable via cognitive control. The results support a Synaptic Theory of Working Memory.