Preparation and characterisation of solid state forms of paracetamol-O-glucuronide
Preparation and characterisation of solid state forms of paracetamol-O-glucuronide
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DOI：
10.1016/j.carres.2011.12.018
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发表时间：
2012-02-15
影响因子：
3.1
通讯作者：
Moynihan, Humphrey A.
中科院分区：
文献类型：
--
作者：
Hayes, John A.;Eccles, Kevin S.;Moynihan, Humphrey A.
描述了药学上重要的代谢产物对乙酰氨基酚-O-葡糖苷酸的合成和结晶。已通过PXRD、DSC和TGA对目标分子的水合和无水形式进行了表征。此外，甲醇溶剂化物进行了分析，包括单晶分析，这代表了该系统的第一个结构的解决方案。(C)2011爱思唯尔有限公司保留所有权利。
The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system. (C) 2011 Elsevier Ltd. All rights reserved.