Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation.
Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation.
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三环类抗抑郁药对脑去甲肾上腺素神经元的反馈抑制：α受体介导。
DOI：
10.1126/science.213833
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发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
T. Usdin
中科院分区：
文献类型：
--
作者：
T. Svensson;T. Usdin
不同受体阻断剂和单单位记录技术的使用表明，三环类抗抑郁药对大脑去甲肾上腺素神经元的反馈抑制是由突触前α受体介导的。长期丙咪嗪治疗后，大鼠大脑蓝斑中的去甲肾上腺素神经元仍然部分抑制，与临床数据一致。然而，它们对丙咪嗪或可乐定的进一步抑制具有抵抗力。
The use of different receptor blocking agents and single-unit recording techniques indicates that feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants is mediated by presynaptic alpha-receptors. After chronic imipramine treatment, noradrenaline neurons in the locus coeruleus of rat brain remained partly depressed, in agreement with clinical data. They were, however, resistant to further inhibition by imipramine or clonidine.