Botulinum toxin in preparation of oral cavity for microsurgical reconstruction
Botulinum toxin in preparation of oral cavity for microsurgical reconstruction
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DOI：
10.3109/00016480902968094
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发表时间：
2010-01-01
影响因子：
1.4
通讯作者：
Moschella, Francesco
中科院分区：
文献类型：
--
作者：
Corradino, Bartolo;Di Lorenzo, Sara;Moschella, Francesco
结论.肉毒杆菌毒素在大唾液腺中的浸润允许在8天后开始暂时减少流涎，并在2个月内恢复正常。在口腔重建手术前进行唾液分泌抑制，可以减少口皮瘘和局部并发症的发生率。目标.唾液停滞是必须接受口腔重建显微外科手术的患者的风险因素，因为口腔中的瘘管形成和局部并发症。作者建议在愈合阶段将肉毒杆菌毒素渗入大唾液腺以暂时减少流涎。患者和方法。在术前阶段，20例口腔癌谁是显微外科重建的候选人进行了唾液腺造影和唾液分泌的定量测量。手术前4天在唾液腺中注射肉毒杆菌毒素。分别于浸润后第3天和第8天进行唾液定量测定，第15天进行唾液腺造影。结果在所有情况下，唾液定量测量显示，减少50%和70%的唾液分泌后72小时和8天，分别。观察到局部并发症的发生率较低。
Conclusions. Infiltration of botulinum toxin in the major salivary glands allows a temporary reduction of salivation that begins 8 days afterwards and returns to normal within 2 months. The inhibition of salivary secretion, carried out before the oral cavity reconstructive surgery, could allow a reduction of the incidence of oro-cutaneous fistulas and local complications. Objectives. Saliva stagnation is a risk factor for patients who have to undergo reconstructive microsurgery of the oral cavity, because of fistula formation and local complications in the oral cavity. The authors suggest infiltration of botulinum toxin in the major salivary glands to reduce salivation temporarily during the healing stage. Patients and methods. During the preoperative stage, 20 patients with oral cavity carcinoma who were candidates for microsurgical reconstruction underwent sialoscintigraphy and a quantitative measurement of the salivary secretion. Injection of botulinum toxin was carried out in the salivary glands 4 days before surgery. The saliva quantitative measurement was repeated 3 and 8 days after infiltration, sialoscintigraphy after 15 days. Results. In all cases, the saliva quantitative measurement revealed a reduction of 50% and 70% of the salivary secretion after 72 h and 8 days, respectively. A lower rate of local complications was observed.