Genotyping of Panamanian Trypanosoma cruzi stocks using the calmodulin 3'UTR polymorphisms
Genotyping of Panamanian Trypanosoma cruzi stocks using the calmodulin 3'UTR polymorphisms
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DOI：
10.1007/s00436-007-0775-5
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发表时间：
2008-02-01
影响因子：
2
通讯作者：
Sousa, Octavio E.
中科院分区：
文献类型：
--
作者：
Brandao, Adeilton;Samudio, Franklyn;Sousa, Octavio E.
最近报道了不同克氏锥虫谱系特异性的钙调素基因3'非翻译区的突变。在本报告中，该分子标记用于24 T基因分型。从巴拿马不同流行地区的人类和媒介中分离出的克氏病毒。发现只有T. cruzi I基因型可能解释了该地区南美锥虫病发病率低于拉丁美洲其他国家的原因。
Mutations in the 3' untranslated region of calmodulin gene have recently been reported to be specific to different Trypanosoma cruzi lineages. In the present report, this molecular marker was used to genotype 24 T. cruzi isolates from humans and vectors from different endemic areas in Panama. The finding of solely T. cruzi I genotype might explain the low morbidity of Chagas' disease in the region when compared to other countries in Latin America.