A first-generation metric linkage disequilibrium map of bovine chromosome 6
A first-generation metric linkage disequilibrium map of bovine chromosome 6
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DOI：
10.1534/genetics.106.060418
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发表时间：
2006-09-01
期刊：
影响因子：
3.3
通讯作者：
Raadsma, Herman W.
中科院分区：
文献类型：
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作者：
Khatkar, Mehar S.;Collins, Andrew;Raadsma, Herman W.
根据433头澳大利亚公牛的220个SNPs基因分型数据，构建了牛6号染色体(BTA6)的度量连锁不平衡(LD)图谱。这个公制LD图的距离以LD单位(LDU)表示，类似于连锁图中的厘米器官。BTA6的LD图谱全长为8.9个LDU。在LD图中，当以千基为单位绘制积分图时，可以观察到高LD的区域(以块表示)和低LD的区域(阶跃)。在最严格的区块定义，即在这些标记的跨度内LDU零增长的一组基因座上，BTA6包括40个区块，占染色体的41%。在块定义的严格性稍低的情况下(LD图上覆盖最多0.2个LDU的一组位置)，高达81%的BTA6由46个块和可能反映重组热点的13个步骤组成。平均扫描半径(LD可能用于作图的距离)为13.3Mb，证实了在荷斯坦-弗里西亚奶牛中存在广泛的LD，这使得这些群体成为全基因组关联研究的理想群体。
We constructed a metric linkage disequilibrium (LD) map of bovine chromosome 6 (BTA6) on the basis of data from 220 SNPs genotyped on 433 Australian dairy bulls. This metric LD map has distances in LD units (LDUs) that are analogous to centimorgans in linkage maps. The LD map of BTA6 has a total length of 8.9 LDUs. Within the LD map, regions of high LD (represented as blocks) and regions of low LD (steps) are observed, when plotted against the integrated map in kilobases. At the most stringent block definition, namely a set of loci with zero LDU increase over the span of these markers, BTA6 comprises 40 blocks, accounting for 41% of the chromosome. At a slightly lower stringency of block definition (a set of loci covering a maximum of 0.2 LDUs on the LD map), up to 81% of BTA6 is spanned by 46 blocks and with 13 steps that are likely to reflect recombination hot spots. The mean swept radius (the distance over which LD is likely to be useful for mapping) is 13.3 Mb, confirming extensive LD in Holstein-Friesian dairy cattle, which makes such populations ideal for whole-genome association studies.