Temporal coding of odor mixtures in an olfactory receptor neuron
Temporal coding of odor mixtures in an olfactory receptor neuron
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DOI：
10.1073/pnas.1100369108
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发表时间：
2011-03-22
影响因子：
11.1
通讯作者：
Carlson, John R.
中科院分区：
文献类型：
--
作者：
Su, Chih-Ying;Martelli, Carlotta;Carlson, John R.
大多数天然气味是混合物，通常引起的感知与其成分引起的感知不同。这种独特的气味品质的出现长期以来一直归因于中央处理。在这里，我们表明，复杂的整合嗅觉信息开始在嗅觉受体神经元（ORN）在果蝇。气味混合物编码的时间动态以及在ORN响应的幅度。ORN可以根据背景激发的水平以不同的持续时间对抑制性气味剂作出反应。ORN响应于具有独特的时间动态的混合物，其反映了组成气味剂的物理化学性质。驱蚊剂避蚊胺（N，N-二乙基-间甲苯酰胺），它减弱了多个ORN的气味反应，不同于ORN特异性抑制剂在其对时间动态的影响。我们的分析揭示了一种方法，通过这种方法，从气味混合物的信息整合开始在ORN，并提供了洞察抑制刺激的感官编码的贡献。
Most natural odors are mixtures and often elicit percepts distinct from those elicited by their constituents. This emergence of a unique odor quality has long been attributed to central processing. Here we show that sophisticated integration of olfactory information begins in olfactory receptor neurons (ORNs) in Drosophila. Odor mixtures are encoded in the temporal dynamics as well as in the magnitudes of ORN responses. ORNs can respond to an inhibitory odorant with different durations depending on the level of background excitation. ORNs respond to mixtures with distinctive temporal dynamics that reflect the physicochemical properties of the constituent odorants. The insect repellent DEET (N, N-diethyl-m-toluamide), which attenuates odor responses of multiple ORNs, differs from an ORN-specific inhibitor in its effects on temporal dynamics. Our analysis reveals a means by which integration of information from odor mixtures begins in ORNs and provides insight into the contribution of inhibitory stimuli to sensory coding.