Ontogenetic quinpirole treatment induces vertical jumping activity in rats.
Ontogenetic quinpirole treatment induces vertical jumping activity in rats.
复制标题
个体发生喹吡罗治疗可诱导大鼠的垂直跳跃活动。
DOI：
10.1016/0014-2999(93)90992-q
复制
发表时间：
1993
影响因子：
5
通讯作者：
Kostrzewa,FP
中科院分区：
文献类型：
--
作者：
Kostrzewa,RM;Guo,J;Kostrzewa,FP
重复个体发育治疗与喹吡罗产生增强喹吡罗诱导打哈欠和抗伤害作用的成年大鼠。我们现在报告一个奇怪的行为发生在这样处理的大鼠跳跃。大鼠从出生起每天用盐酸喹吡罗（3.0 mg/kg/天× 28天i. p.，盐形式）或盐水载体。每天注射后，观察大鼠至少1小时。从出生后第18天开始，喹吡罗治疗与跳跃行为的出现有关。出生后第20天，盐酸喹吡罗（0.10-3.0 mg/kg）呈剂量-效应关系，最大跳跃活动发生在3.0 mg/kg剂量后30 - 150 min。在出生后第26天，盐酸螺哌隆（0.30 mg/kg i. p.）和SCH 23390 HCl（0.30 mg/kg i.p.）减弱了喹吡罗效应。在34天时，跳跃反应几乎不存在。与年龄相关的跳跃行为似乎是由超敏多巴胺受体介导的异常反应的另一种表现。基于多巴胺D1和D2受体拮抗剂减弱这种作用的能力，喹吡罗诱导的跳跃行为可能是多巴胺D1和D2受体类型协同作用的反映。
Repeated ontogenetic treatment with quinpirole produces enhanced quinpirole-induced yawning and antinociceptive actions in adult rats. We now report the occurence of a bizarre behavior jumping inrats so treated. Rats were treated daily from birth with quinpirole HCl (3.0 mg/kg per day × 28 days i.p., salt form) or saline vehicle. After each daily injection, the rats were observed for at least 1 h. Starting on the 18th day after birth, quinpirole treatment was associated with the appearance of jumping behavior. On the 20th day after birth a dose-effect relationship was found for quinpirole HCl (0.10–3.0 mg/kg), with maximal jumping activity occurring between 30 and 150 min after the 3.0 mg/kg dose. On the 26th day after birth, both spiperone HCl (0.30 mg/kg i.p.) and SCH 23390 HCl (0.30 mg/kg i.p.) attenuated the quinpirole effect. At 34 days the jumping response was virtually absent. The age-related jumping behavior appears to be another manifestation of the abnormal responses meduated by supersensitized dopamine receptors in quinpirole-primed rats. Based on the ability of dopamine D1and D2receptor antagonists to attenuate this effect, quinpirole-induced jumping behavior may be a reflection of cooperativity of dopamine D1and D2receptor types.