Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers
Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers
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DOI：
10.1097/01.pgp.0000101082.35393.84
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Pasini, B
中科院分区：
文献类型：
--
作者：
Carcangiu, ML;Radice, P;Pasini, B
尽管BRCA1和BRCA2胚系突变携带者发生输卵管癌的报道越来越多，但人们对其可能的前驱病变的性质和频率知之甚少。本研究的目的是调查26例BRCA1和BRCA2胚系突变的女性患者的非典型增殖性输卵管病变的发生情况，这些患者接受预防性输卵管卵巢切除术，其卵巢组织学检查均为阴性。49例子宫肌瘤子宫切除联合输卵管切开术患者的输卵管作为对照。在22例BRCA1突变的妇女中，有两例原位癌和两例输卵管上皮不典型增生。BRCA2突变妇女和49名对照妇女的输卵管没有表现出任何不典型的增殖。BRCA1突变携带者的输卵管上皮细胞增殖性病变，包括原位癌的频率似乎增加。因此，建议在手术预防卵巢癌时切除并彻底检查输卵管。
Although growing numbers of tubal carcinomas in carriers of BRCA1 and BRCA2 germline mutations have been reported, very little is known about the nature and frequency of their possible precursor lesions. The aim of this study is to investigate the occurrence of atypical proliferative tubal lesions in grossly normal fallopian tubes from 26 women with BRCA1 and BRCA2 germline mutations who underwent prophylactic salpingo-ooophorectomy and whose ovaries were histologically negative for carcinoma. Fallopian tubes from 49 women who had undergone hysterectomy with salpingo-oophorectomy for uterine leiomyoma served as controls. In the 22 BRCA1-mutated women, there were two in situ carcinomas and two atypical hyperplasias of the tubal epithelium. The tubes of the BRCA2-mutated women and of the 49 control women did not show any atypical proliferation. The frequency of proliferative lesions of the tubal epithelium, including in situ carcinoma, appears to be increased in BRCA1 mutation carriers. Removal and thorough examination of the fallopian tubes at the time of surgical prophylaxis for ovarian cancer is therefore recommended.