Addition of Prostate Volume and Prostate-specific Antigen Density to Memorial Sloan Kettering Cancer Center Prostate Cancer Nomograms.
Addition of Prostate Volume and Prostate-specific Antigen Density to Memorial Sloan Kettering Cancer Center Prostate Cancer Nomograms.
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DOI：
10.1016/j.euros.2021.06.002
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发表时间：
2021-08
影响因子：
2.5
通讯作者：
Hu JC
中科院分区：
文献类型：
--
作者：
Tzeng M;Vertosick E;Basourakos SP;Eastham JA;Ehdaie B;Scardino PT;Vickers AJ;Hu JC
前列腺特异性抗原（PSA）密度是前列腺癌的既定预后标志物。我们研究了在纪念斯隆-凯特琳癌症中心列线图中纳入PSA密度或前列腺体积是否能提高根治性前列腺切除术（RP）后生化复发（BCR）的预测。在纳入的11725名男性中，有2140人发展为BCR。当加入RP前或RP后模型时，PSA密度和前列腺体积均与BCR无关（所有p值≥0.10），C指数的变化非常小（最大变化，0.002）。排除了前列腺体积和2005年后接受治疗的患者，结果是稳健的。没有理由在BCR列线图中增加前列腺体积或PSA密度。将前列腺体积或前列腺特异性抗原密度加入到纪念斯隆-凯特琳癌症中心的预测方案中并不能提高前列腺切除后前列腺癌复发的预测。
Prostate-specific antigen (PSA) density is an established prognostic marker for prostate cancer. We investigated whether the inclusion of PSA density or prostate volume in the Memorial Sloan Kettering Cancer Center nomograms improves the prediction of biochemical recurrence (BCR) after radical prostatectomy (RP). Among the 11 725 men included, 2140 developed BCR. Neither PSA density nor prostate volume was associated with BCR when added to either the pre-RP or post-RP model (all p values ≥0.10) and changes in the C index were very small (largest change, 0.002). The results were robust to exclusion of outlying prostate volumes and restriction to patients treated after 2005. There is no justification for adding prostate volume or PSA density to BCR nomograms. Addition of prostate volume or prostate-specific antigen density to Memorial Sloan Kettering Cancer Center prediction schemes did not improve the prediction of recurrence of prostate cancer after removal of the prostate.
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影响因子：
2.6
作者：
Moschini, Marco;Gandaglia, Giorgio;Briganti, Alberto
通讯作者：
Briganti, Alberto
影响因子：
6.6
作者：
Freedland, SJ;Kane, CJ;Aronson, WJ
通讯作者：
Aronson, WJ
影响因子：
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作者：
Magheli, Ahmed;Rais-Bahrami, Soroush;Gonzalgo, Mark L.
通讯作者：
Gonzalgo, Mark L.
影响因子：
6.6
作者：
Freedland, SJ;Wieder, JA;Aronson, WJ
通讯作者：
Aronson, WJ
DOI：
10.1016/j.juro.2018.09.060
发表时间：
2019-03
期刊：
The Journal of urology
影响因子：
--
作者：
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通讯作者：
Fine SW