Modulation of Dysarthropneumophonia by Low-Frequency STN DBS in Advanced Parkinson's Disease
Modulation of Dysarthropneumophonia by Low-Frequency STN DBS in Advanced Parkinson's Disease
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DOI：
10.1002/mds.23538
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发表时间：
2011-03-01
影响因子：
8.6
通讯作者：
Defebvre, Luc
中科院分区：
文献类型：
--
作者：
Moreau, Caroline;Pennel-Ployart, Odile;Defebvre, Luc
背景：帕金森性构音障碍（典型特征为低语速、音调单调和节奏异常）常伴有步态障碍。丘脑下核深部脑刺激（STN DBS）对构音障碍的长期影响尚不清楚。方法：考虑到STN DBS对步态障碍的已知改善，我们在三种双盲随机条件下分析了11名晚期PD患者的语音清晰度、空气动力学和声学参数：“defined Off”、60 Hz STN DBS和130 Hz STN DBS。结果：在60 Hz STN DBS中，空气动力学语音参数的改善伴随着显著的临床获益。结论：低频STN DBS慢性治疗可能对关节呼吸障碍有有益影响，甚至对晚期PD患者也是如此。(C) 2011运动障碍学会
Background: Parkinsonian dysarthria (as typically characterized by hypophonia, monotony of pitch, and rhythm abnormalities) is often accompanied by gait disturbances. The long-term effect of subthalamic nucleus deep brain stimulation (STN DBS) on dysarthria remains unclear.Methods: Given STN DBS's known improvement of gait disorders, we analyzed speech intelligibility and aerodynamic and acoustic parameters in 11 advanced PD patients in three double-blind, randomized conditions: "defined Off,'' 60 Hz STN DBS and 130 Hz STN DBS.Results: An improvement in aerodynamic speech parameters during 60 Hz STN DBS was accompanied by significant clinical benefit.Conclusions: Chronic treatment with low-frequency STN DBS may have a beneficial impact on dysarthropneumophonia, even in advanced PD patients. (C) 2011 Movement Disorder Society