Use of anti-tumor necrosis factor agents: A possible therapy for vitiligo
Use of anti-tumor necrosis factor agents: A possible therapy for vitiligo
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使用抗肿瘤坏死因子药物：白癜风的一种可能疗法
DOI：
10.1016/j.mehy.2008.12.033
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发表时间：
2009-05-01
影响因子：
4.7
通讯作者：
Gao, Tianwen
中科院分区：
文献类型：
--
作者：
Lv, Yajie;Li, Qiang;Gao, Tianwen
白癜风是一种脱色性皮肤疾病，由表皮中黑素细胞的丧失引起。虽然白癜风的确切病因尚未确定，但在白癜风患者中经常观察到免疫反应的异常。此外，一些白癜风患者的皮损中肿瘤坏死因子-α水平较高。肿瘤坏死因子-α是一种重要的多效性细胞因子，具有很强的促炎作用。越来越多的证据表明，肿瘤坏死因子-α在包括强直性脊柱炎(AS)在内的某些自身免疫性疾病的发病机制中起着重要作用。用抗肿瘤坏死因子药物英夫利昔单抗治疗，随着AS的改善，患者的白癜风皮损也逐渐消失。因此，我们推测肿瘤坏死因子-α在白癜风发病中起重要作用。一方面，肿瘤坏死因子-α通过诱导多种凋亡途径破坏黑素细胞。另一方面，肿瘤坏死因子-α抑制黑素细胞干细胞分化。抗肿瘤坏死因子治疗白癜风可能是一种有效的治疗方法。(C)2009爱思唯尔有限公司。保留所有权利。
Vitiligo is a depigmenting skin disorder resulting from the loss of melanocytes in the epidermis. Although the exact aetiology of vitiligo has not yet been established, the abnormal immune responses have been frequently observed in vitiligo patients. Moreover, some vitiligo patients show higher lesion levels of tumor necrosis factor (TNF)-alpha. TNF-alpha is an important pleiotropic cytokine that exerts potent pro-inflammatory effects. There is growing evidence that TNF-alpha plays an important role in the pathomechanism process of some autoimmunity diseases, including ankylosing spondylitis (AS). Treated with anti-TNF agents infliximab, with the improvement of AS, a patient's vitiligo lesions also faded out. Therefore, we hypothesized that TNF-alpha play an important role in vitiligo. On the one hand, TNF-alpha destroys melanocytes through induction of various apoptotic pathways. On the other hand, TNF-alpha inhibits melanocyte stem cells differentiation. Anti-TNF therapy may be an effective treatment for vitiligo. (C) 2009 Elsevier Ltd. All rights reserved.