CONSEQUENCES OF RESTRICTED FEEDING REFEEDING CYCLES IN LEAN AND OBESE FEMALE ZUCKER RATS
CONSEQUENCES OF RESTRICTED FEEDING REFEEDING CYCLES IN LEAN AND OBESE FEMALE ZUCKER RATS
复制标题
DOI：
10.1093/jn/116.2.290
复制
发表时间：
1986-02-01
影响因子：
4.2
通讯作者：
CLEARY, MP
中科院分区：
文献类型：
--
作者：
CLEARY, MP
精益和肥胖的雌性Zucker大鼠进行了4个，6周的限制喂养/再喂养周期。限制喂养的瘦型（RL）大鼠在每个周期中体重减轻，然后恢复到与自由喂养的瘦型（AL）大鼠在每个再喂养期结束时相同的体重。在限制摄入的最后一段时间后，RL大鼠的子宫旁和腹膜后垫重量和脂肪细胞大小显着低于AL大鼠，但其器官生长和脂肪生成酶不受影响。在最后的再喂养期后，RL和AL大鼠之间除了累积食物摄入量外没有差异。在第一阶段的限制摄入限制喂养，肥胖（RO）大鼠体重没有下降，但是，他们无法达到体重的自由采食，肥胖（AO）大鼠在随后的再喂养期间。在以后的周期中，RO大鼠体重减轻和恢复，但体重总是显著低于AO大鼠。在最终的限制喂养和再喂养期后，RO和AO大鼠的脂肪垫重量和细胞数量显着降低，但脂肪细胞大小不受影响。在限制摄入的最后一段时间后，RO大鼠的肝脏重量和脂肪生成酶低于AO大鼠，但在最后的再喂养期后与AO大鼠相似。在RO大鼠中发现对心脏和肾脏生长的永久性影响。肥胖大鼠对这种形式的饮食干预的反应似乎与瘦大鼠不同。
Lean and obese female Zucker rats underwent four, 6-wk cycles of restricted feeding/refeeding. Restricted-fed, lean (RL) rats lost and then regained sufficient weight in each cycle to weigh the same amount as ad libitum-fed, lean (AL) rats at the end of each refeeding period. After the final period of restricted intake, RL rats had significantly lower parametrial and retroperitoneal pad weights and fat cell sizes than AL rats, but their organ growth and lipogenic enzymes were not affected. After the final refeeding period, there were no differences between RL and AL rats except in cumulative food intake. During the first period of restricted intake restricted-fed, obese (RO) rats did not lose weight; however, they were unable to attain the body weight of ad libitum-fed, obese (AO) rats during the subsequent refeeding period. In later cycles, RO rats lost and regained weight, but always weighed significantly less than AO rats. Following the final restricted feeding and refeeding periods, fat pad weights and cell numbers were significantly lower in RO and AO rats, but fat cell size was not affected. Liver weight and lipogenic enzymes were lower in RO than in AO rats after the final period of restricted intake, but were similar to AO rats after the final refeeding period. Permanent effects on heart and kidney growth were found in RO rats. Obese rats appeared to respond differently than lean rats to this form of dietary intervention.