Compliance to treatment for hypertension in elderly patients: the SHEP pilot study. Systolic Hypertension in the Elderly Program.
Compliance to treatment for hypertension in elderly patients: the SHEP pilot study. Systolic Hypertension in the Elderly Program.
复制标题
老年患者高血压治疗的依从性：SHEP 试点研究。
DOI：
10.1093/geronj/42.5.552
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Smith,J
中科院分区：
文献类型：
--
作者：
Black,DM;Brand,RJ;Greenlick,M;Hughes,G;Smith,J
评估 60 岁以上人群对抗高血压治疗方案的依从性是老年人收缩期高血压计划 (SHEP) 试点研究的主要目标。该研究将 551 名 60 岁以上（平均年龄 = 72 岁）的男性和女性随机分组，进行双盲试验，其中包括氯噻酮或安慰剂。治疗方案依从性的三项指标——药丸计数、自我报告和尿液氯噻酮测定——均表明 80% 至 90% 的参与者在随机分组后 3 个月和 1 年内具有较高的依从性。活性组和安慰剂组的服药依从性相似，尽管安慰剂组在 1 年时停止研究药物的比率高于活性组。所有年龄组的依从性都很高，包括 80 岁以上的患者。这些数据表明，老年患者对抗高血压药物的依从性较高。
Assessing the compliance of people over 60 years of age and older with an antihypertensive treatment regimen was a major objective of the systolic Hypertension in the Elderly Program (SHEP) pilot study. The study randomized 551 men and women over the age of 60 (mean age = 72 years) to a stepped care treatment that included chlorthalidone or placebo in a double-blind trial. Three measures of compliance to treatment protocol — pill count, self-report, and a urine chlorthalidone assay — all indicated high levels of compliance in 80 to 90% of participants at 3 months and 1 year after randomization. Pill-taking compliance was similar in the active and placebo groups, although the rate of discontinuance from study medications at 1 year was higher in the placebo than in the active group. Compliance was high in all age categories, including those over age 80. These data suggest that elderly patients can achieve high levels of compliance with antihypertensive medications.