Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts
Phylogenetic analysis of GB viruses A and C: evidence for cospeciation between virus isolates and their primate hosts
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DOI：
10.1099/0022-1317-80-9-2329
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发表时间：
1999-09-01
影响因子：
3.8
通讯作者：
de Lamballerie, X
中科院分区：
文献类型：
--
作者：
Charrel, RN;De Micco, P;de Lamballerie, X
GB病毒A和C(GBV-A和GBV-C)已从人类和非人灵长类动物中分离到。基于全长多蛋白的系统发育分析表明，这两种病毒有一个共同的祖先。现已确定，对GBV-A E2和NS5区的亚基因组氨基酸序列以及5‘非编码区的345个核苷酸片段的分析能够重现通过完整的多蛋白序列分析所获得的系统发育关系。利用数据库中的5‘NC序列，将GBV-A分离株分为8个遗传群体，每个群体与特定的灵长类宿主密切相关。对灵长类宿主的表珠蛋白基因序列和GBV-A和GBV-C分离株的完整多蛋白序列进行的系统发育分析表明，在3500万年的时间里，共种机制可能参与了病毒的进化。
GB viruses A and C (GBV-A and GBV-C) have been isolated from humans and non-human primates. Phylogenetic analysis based on full-length polyproteins suggests that these two viruses have a common ancestor. It has now been determined that analysis of subgenomic amino acid sequences in the E2 and NS5 regions of GBV-A and a 345 nucleotide segment in the 5' non-coding (5'NC) region was able to reproduce the phylogenetic relationships obtained by complete polyprotein sequences analysis. Using 5'NC sequences from databases, GBV-A isolates were discriminated into eight genetic groups, each one closely associated with specific primate hosts. Phylogenetic analyses performed on sequences from the epsilon-globin genes of primate hosts on one hand and complete polyprotein sequences from GBV-A and GBV-C isolates on the other suggest that a mechanism of cospeciation could be involved in virus evolution over a period of 35 million years.