Long-term quality of life after breast cancer:: Comparison of 8-year survivors with population controls
Long-term quality of life after breast cancer:: Comparison of 8-year survivors with population controls
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DOI：
10.1200/jco.1998.16.2.487
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发表时间：
1998-02-01
影响因子：
45.3
通讯作者：
Mâsse, B
中科院分区：
文献类型：
--
作者：
Dorval, M;Maunsell, E;Mâsse, B
目的：诊断后8年的乳腺癌幸存者的生活质量进行了比较，年龄相仿的妇女谁从来没有面对癌症（controls.Methods）：227例乳腺癌患者在1984年首次接受治疗的连续系列的幸存者进行了这项研究。随机数字拨号被用来确定控制与相同的年龄和居住分布的幸存者。生活质量进行了评估，在身体健康，功能状态，心理困扰，和社会functioning.Results：参与获得96%（n = 124）的129个合格的幸存者和61%（n = 262）的427个潜在的合格的控制。与对照组相比，幸存者中报告积极生活质量结局的比例始终较小，但这些差异通常较小且无统计学意义。当仅限于在整个随访期间保持无疾病的女性（n = 98）时，幸存者的生活质量与对照组相似，除了与伴侣生活的女性的手臂问题和性满意度。相比之下，幸存者谁开发复发或新的原发性乳腺癌（n = 26）经历了更糟糕的生活质量在所有领域，但social functioning.Conclusion：在大多数领域和妇女没有进一步的疾病事件诊断后，生活质量似乎并没有永久性和全球性的乳腺癌受损。因此，乳腺癌幸存者谁仍然免费的疾病可能不需要有组织的后期心理随访，以提高生活质量。然而，手臂问题和性行为是两个领域，可能仍然需要作出额外努力，以提高长期幸存者的生活质量。(C)1998年，美国临床肿瘤学会。
Purpose: Quality of life of breast cancer survivors 8 years after diagnosis was compared with that among similarly aged women who had never confronted cancer (controls).Methods: Survivors of a consecutive series of 227 breast cancer patients first treated in 1984 were approached for this study. Random-digit dialing was used to identify controls with the same age and residential distribution as the survivors. Quality of life was assessed in terms of physical health, functional status, psychologic distress, and social functioning.Results: Participation was obtained from 96% (n = 124) of 129 eligible survivors and 61% (n = 262) of 427 potentially eligible controls. Consistently smaller proportions of survivors reported positive quality-of-life outcomes compared with controls, but these differences were generally small and nonsignificant statistically. When limited to women who remained free of disease over the entire follow-up period (n = 98), survivors' quality of life was similar to that among controls, with the exception of arm problems and sexual satisfaction for those women who lived with a partner. In contrast, survivors who developed recurrence or new primary breast cancer (n = 26) experienced a worse quality of life in all domains except social functioning.Conclusion: In most domains and for women without further disease events after diagnosis, quality of life does not seem to be permanently and globally impaired by breast cancer. Consequently, breast cancer survivors who remain free of disease probably do not need organized late psychosocial follow-up to improve qualify of life. However, arm problems and sexuality are two areas in which additional effort may be still needed to improve quality of life of long-term survivors. (C) 1998 by American Society of Clinical Oncology.