Prognostic value of preoperative peripheral neutrophilto-lymphocyte ratio in patients with HBV-associated hepatocellular carcinoma after radical hepatectomy
Prognostic value of preoperative peripheral neutrophilto-lymphocyte ratio in patients with HBV-associated hepatocellular carcinoma after radical hepatectomy
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术前外周血中性粒细胞/淋巴细胞比值对乙型肝炎病毒相关性肝细胞癌根治性肝切除术后患者的预后价值
DOI：
10.1007/s12032-013-0721-6
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发表时间：
2013-12-01
期刊：
影响因子：
3.4
通讯作者：
Peng, Bao-Gang
中科院分区：
文献类型：
--
作者：
Fu, Shun-Jun;Shen, Shun-Li;Peng, Bao-Gang
中性粒细胞与淋巴细胞比率（NLR）是一种炎症指数，被认为是肝细胞癌（HCC）的预后预测因子。本研究旨在评估乙型肝炎病毒（HBV）相关HCC患者根治性肝切除术后术前外周血NLR的预后价值。临床数据收集于接受根治性肝切除术的hbv相关HCC患者。NLR通过术前血常规检查的淋巴细胞和中性粒细胞计数计算。对人口统计学、实验室分析和组织病理学数据进行分析。共选取282例患者，按NLR截断值2划分。多因素分析显示，NLR >2是无病生存差的独立预后预测因子[危险比(HR) = 1.362；95%置信区间（CI） 1.025 ~ 1.811；P = 0.033]和总生存率（HR = 1.434; 95% CI 1.044-1.970; P = 0.023）。对于血清AFP水平正常的hbv相关HCC患者，NLR对预后有较好的预测价值。这些结果表明，NLR是乙肝相关HCC根治性肝切除术后患者（包括afp正常患者）无病生存和总生存的独立指标。
Neutrophil-to-lymphocyte ratio (NLR), an inflammation index, is considered a prognostic predictor of hepatocellular carcinoma (HCC). This study aimed to evaluate the prognostic value of preoperative peripheral NLR in patients with hepatitis B virus (HBV)-associated HCC after radical hepatectomy. Clinical data were collected from patients with HBV-associated HCC who underwent radical hepatectomy. NLR was calculated from lymphocyte and neutrophil counts on preoperative routine blood tests. Demographics, laboratory analyses, and histopathological data were analyzed. A total of 282 patients were selected and divided by the cutoff NLR value of 2. Multivariate analysis showed that NLR > 2 was an independent prognostic predictor of poor disease-free survival [hazard ratio (HR) = 1.362; 95 % confidence interval (CI) 1.025-1.811; P = 0.033] and overall survival (HR = 1.434; 95 % CI 1.044-1.970; P = 0.023). NLR had a good predictive value for prognosis in patients with HBV-associated HCC who had normal serum AFP level. These results suggested that NLR is an independent indicator of both disease-free survival and overall survival in patients with HBV-associated HCC after radical hepatectomy, including AFP-normal patients.