Differential prefrontal and frontotemporal oxygenation patterns during phonemic and semantic verbal fluency
Differential prefrontal and frontotemporal oxygenation patterns during phonemic and semantic verbal fluency
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DOI：
10.1016/j.neuropsychologia.2012.03.009
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发表时间：
2012-06-01
期刊：
影响因子：
2.6
通讯作者：
Ehlis, Ann-Christine
中科院分区：
文献类型：
--
作者：
Tupak, Sara V.;Badewien, Meike;Ehlis, Ann-Christine
运动伪影仍然被认为是显性语言产生的成像研究的一个问题。这种运动敏感性可以通过功能近红外光谱（fNIRS）来克服。在本研究中，50名健康受试者进行了联合语音和语义的显性言语流畅性任务，而额叶和颞叶皮层的氧合作用多通道fNIRS记录。结果表明，部分分离的音素和语义词的生成，同样增加了两种类型的任务，而前部和上级前额叶皮层的氧合专门在音素流畅性激活。此外，一般的左侧化被发现在语义处理过程中更明显。这些发现与早期的成像和病变研究一致，强调颞叶在语义词产生中的关键作用，而音素处理似乎依赖于完整的额叶功能。(C)2012爱思唯尔有限公司保留所有权利。
Movement artifacts are still considered a problematic issue for imaging research on overt language production. This motion-sensitivity can be overcome by functional near-infrared spectroscopy (fNIRS). In the present study, 50 healthy subjects performed a combined phonemic and semantic overt verbal fluency task while frontal and temporal cortex oxygenation was recorded using multi-channel fNIRS. Results showed a partial dissociation for phonemic and semantic word generation with equally increased oxygenation in frontotemporal cortices for both types of tasks whereas anterior and superior prefrontal areas were exclusively activated during phonemic fluency. Also, a general left-lateralization was found being more pronounced during semantic processing. These findings line up with earlier imaging and lesion studies emphasizing a crucial role of the temporal lobe for semantic word production, whereas phonemic processing seems to depend on intact frontal lobe function. (C) 2012 Elsevier Ltd. All rights reserved.