P-DICHLOROBENZENE EXPOSURE AMONG 1,000 ADULTS IN THE UNITED-STATES
P-DICHLOROBENZENE EXPOSURE AMONG 1,000 ADULTS IN THE UNITED-STATES
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DOI：
10.1080/00039896.1995.9935954
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发表时间：
1995-07-01
期刊：
影响因子：
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通讯作者：
PIRKLE, JL
中科院分区：
文献类型：
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作者：
HILL, RH;ASHLEY, DL;PIRKLE, JL
对二氯苯在美国被广泛用作室内除臭剂、驱虫剂和聚合物的前体。在之前的一项针对阿肯色州儿童的研究中，我们发现96%的儿童尿液中可检测到2,5-二氯酚（对二氯苯的代谢物）的浓度。在目前的研究中，我们发现，在生活在美国各地的1000名成年人的样本中，98%的人尿液中可检测到2,5-二氯酚，96%的人血液中可检测到对二氯苯。尿液中2,5-二氯酚浓度最高可达8700 μ g/l（中位和平均浓度分别为30 μ g/l和200 μ g/l）。对二氯苯血药浓度最高可达49 μ g/l，中位浓度和平均浓度分别为0.33 μ g/l和2.1 μ g/l。尿中2,5-二氯酚与血中对二氯苯的Pearson相关系数为。82 (p.40)。将这些结果与其他研究的数据结合起来看，这些综合数据表明，对二氯苯是一种常见的、世界范围内的污染物。接触对二氯苯的情况非常普遍，再加上它可能对健康产生不利影响，这表明需要进行更详细的研究，包括对接触人群的长期健康影响的研究。
p-Dichlorobenzene is used widely in the United States as a room deodorizer, a moth repellent, and a precursor for a polymer. In a previous study of selected children in Arkansas, we found that 96% of the children had detectable urinary concentrations of 2,5-dichlorophenol, the metabolite of p-dichlorobenzene. In the current study, we found that, in a sample of 1 000 adults who lived throughout the United States, 98% had detectable levels of 2,5-dichlorophenol in their urine, and 96% had detectable levels of p-dichlorobenzene in their blood. Urinary 2,5-dichlorophenol concentrations ranged up to 8 700 mu g/l (median and mean concentrations of 30 mu g/l and 200 mu g/l, respectively). p-Dichlorobenzene blood concentrations ranged up to 49 mu g/l, with median and mean concentrations of 0.33 mu g/l and 2.1 mu g/l, respectively. The Pearson correlation coefficient for 2,5-dichlorophenol in urine and p-dichlorobenzene in blood was .82 (p.40). When these results are viewed with data from other studies, the collective data show that p-dichlorobenzene is a common, worldwide contaminant. The high prevalence of exposure to p-dichlorobenzene, coupled with its potential for adverse health effects, indicate the need for more detailed studies, including studies of long-term health effects on exposed populations.