A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania.
A ten year review of the sickle cell program in Muhimbili National Hospital, Tanzania.
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DOI：
10.1186/s12878-018-0125-0
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Mmbando, Bruno P
中科院分区：
文献类型：
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作者：
Makani, Julie;Tluway, Furahini;Mmbando, Bruno P
背景：非洲镰状细胞病（SCD）负担最重，但很少有大型、系统的研究提供可靠的疾病谱描述。坦桑尼亚每年有1.1万例SCD新生儿，该国建立了Muhimbili镰状细胞项目，旨在提高非洲对SCD的认识。我们报告了在Muhimbili国立医院（MNH）头10年看到的SCD的概况。方法：在MNH发现的已知或怀疑患有SCD的个体在临床和实验室进行SCD检测，进行血液学和生化分析。种族是自我报告的。记录了SCD的临床和实验室特征。与非残疾人士及三个不同年龄组别(
BACKGROUND: Africa has the highest burden of Sickle cell disease (SCD) but there are few large, systematic studies providing reliable descriptions of the disease spectrum. Tanzania, with 11,000 SCD births annually, established the Muhimbili Sickle Cell program aiming to improve understanding of SCD in Africa. We report the profile of SCD seen in the first 10years at Muhimbili National Hospital (MNH).METHODS: Individuals seen at MNH known or suspected to have SCD were enrolled at clinic and laboratory testing for SCD, haematological and biochemical analyses done. Ethnicity was self-reported. Clinical and laboratory features of SCD were documented. Comparison was made with non-SCD population as well as within 3 different age groups (