Auditory processing and sensory behaviours in children with autism spectrum disorders as revealed by mismatch negativity
Auditory processing and sensory behaviours in children with autism spectrum disorders as revealed by mismatch negativity
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DOI：
10.1016/j.bandc.2014.01.016
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发表时间：
2014-04-01
影响因子：
2.5
通讯作者：
Gutierrez, Roberto
中科院分区：
文献类型：
--
作者：
Ludlow, Amanda;Mohr, Bettina;Gutierrez, Roberto
感觉功能障碍可能是自闭症谱系障碍（ASD）儿童的关键特征之一。本研究旨在探讨ASD儿童的听觉变化检测，以确定无意义和有意义的言语刺激的事件相关电位。11名诊断为自闭症谱系障碍的高功能男孩（平均年龄= 13.0; SD = 1.08）和11名典型发育男孩（平均年龄= 13.7; SD = 1.5）参与了失配负性（MMN）范式。结果显示，与TD对照组相比，ASD儿童表现出显着减少的MMN反应的话和假词在大脑的额叶区域，也显着减少他们的激活的话在中央顶叶区域。为了测试感觉处理和听觉处理之间的关系，儿童完成了成人和青少年感觉概况。正如预测的那样，ASD儿童表现出更极端的感觉行为，并且在三个感觉象限（感觉灵敏度，低登记和感觉回避）中显着高于他们通常发育的对照组。重要的是，只有听觉感官灵敏度能够解释的差异显示的话在额叶和中央顶叶区域控制组的影响时，揭示了一个负相关的感官灵敏度分数越高，激活反应的话。我们讨论了如何在ASD的感觉行为的表达可能会导致自动语言处理的神经生理机制不足。(C)2014 Elsevier Inc. All rights reserved.
Sensory dysfunctions may underlie key characteristics in children with Autism Spectrum Disorders (ASD). The current study aimed to investigate auditory change detection in children with ASD in order to determine event-related potentials to meaningless and meaningful speech stimuli. 11 high functioning boys with a diagnosis of autism spectrum disorders (mean age = 13.0; SD = 1.08) and 11 typically developing boys (mean age = 13.7; SD = 1.5) participated in a mismatch negativity (MMN) paradigm. Results revealed that compared to TD controls, the children with ASD showed significantly reduced MMN responses to both words and pseudowords in the frontal regions of the brain and also a significant reduction in their activation for words in the Central Parietal regions. In order to test the relationship between sensory processing and auditory processing, children completed the Adult and Adolescent Sensory Profile. As predicted, the children with ASD showed more extreme sensory behaviours and were significantly higher than their typically developing controls across three of the sensory quadrants (sensory sensitivity, low registration and sensory avoidance). Importantly, only auditory sensory sensitivity was able to account for the differences displayed for words in the frontal and central parietal regions when controlling for the effect of group, revealing an inverse relationship of the higher sensory sensitivity scores the less activation in response for words. We discuss how the expression of sensory behaviours in ASD may result in deficient neurophysiological mechanisms underlying automatic language processing. (C) 2014 Elsevier Inc. All rights reserved.