Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring.
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring.
复制标题
用于无创皮质醇监测的可穿戴适体场效应晶体管传感系统。
DOI：
10.1126/sciadv.abk0967
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发表时间：
2022-01-07
期刊：
影响因子：
13.6
通讯作者：
Emaminejad S
中科院分区：
文献类型：
--
作者：
Wang B;Zhao C;Wang Z;Yang KA;Cheng X;Liu W;Yu W;Lin S;Zhao Y;Cheung KM;Lin H;Hojaiji H;Weiss PS;Stojanović MN;Tomiyama AJ;Andrews AM;Emaminejad S
开发了一款智能手表，用于无创压力生物标志物数据采集，为佩戴者提供实时反馈。用于个性化监测的可穿戴技术需要跟踪通常以低水平存在的生物标志物的传感器。皮质醇是一种重要的压力生物标志物，存在于汗液中的浓度很低。以前的可穿戴传感系统仅限于微摩尔-毫摩尔范围内的分析物。为了克服这一点和其他限制，我们开发了一种灵活的场效应晶体管（FET）生物传感器阵列，利用以前未报道的皮质醇适体耦合到纳米薄膜In 2 O3 FET。皮质醇水平通过适体的分子识别来确定，其中结合被转换为FET上的电信号。皮质醇作为压力生物标志物的生理相关性通过跟踪特里尔社会压力测试中参与者的唾液皮质醇水平并建立昼夜唾液和汗液样本中皮质醇之间的相关性来证明。这些相关性推动了基于适配体-FET阵列的智能手表的开发和身体验证，该智能手表配备了定制的、多通道的、自参考的和自主的源测量单元，能够实现无缝的、实时的皮质醇汗液感测。
A smartwatch was developed for noninvasive stress biomarker data acquisition that provides real-time feedback to the wearer. Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In2O3 FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array–based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.
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影响因子：
14.9
作者：
Renaud de la Faverie A;Guédin A;Bedrat A;Yatsunyk LA;Mergny JL
通讯作者：
Mergny JL
DOI：
10.1039/c5an02387d
发表时间：
2016-03-21
期刊：
The Analyst
影响因子：
--
作者：
Jia M;Chew WM;Feinstein Y;Skeath P;Sternberg EM
通讯作者：
Sternberg EM
影响因子：
8.9
作者：
Ganguly, Antra;Lin, Kai Chun;Prasad, Shalini
通讯作者：
Prasad, Shalini
影响因子：
17.1
作者：
Ishikawa FN;Curreli M;Chang HK;Chen PC;Zhang R;Cote RJ;Thompson ME;Zhou C
通讯作者：
Zhou C
影响因子：
4.2
作者：
Hu, Jiaming;Easley, Christopher J.
通讯作者：
Easley, Christopher J.