Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents
Adeno-Associated Virus Antibody Profiles in Newborns, Children, and Adolescents
复制标题
DOI：
10.1128/cvi.05107-11
复制
发表时间：
2011-09-01
影响因子：
--
通讯作者：
Wilson, James M.
中科院分区：
文献类型：
--
作者：
Calcedo, Roberto;Morizono, Hiroki;Wilson, James M.
由于先前野生型AAV的自然感染，针对腺相关病毒（AAV）载体的中和抗体（NAb）可显著限制基因转移。研究了人受试者（0至18岁）中针对AAV血清型2（AAV 2）和AAV 8的NAb滴度。NAb患病率在出生时为中等，从7个月到11个月显著下降，然后在儿童和青春期逐渐增加。
Neutralizing antibodies (NAb) to an adeno-associated virus (AAV) vector due to previous natural infection with wild-type AAV can significantly limit gene transfer. NAb titers to AAV serotype 2 (AAV2) and AAV8 in human subjects (0 to 18 years) were studied. NAb prevalence is moderate at birth, decreases markedly from 7 to 11 months, and then progressively increases through childhood and adolescence.