PREVALENCE OF CAROTID ATHEROSCLEROSIS IN DIABETIC-PATIENTS - ULTRASOUND HIGH-RESOLUTION B-MODE IMAGING ON CAROTID ARTERIES
PREVALENCE OF CAROTID ATHEROSCLEROSIS IN DIABETIC-PATIENTS - ULTRASOUND HIGH-RESOLUTION B-MODE IMAGING ON CAROTID ARTERIES
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DOI：
10.2337/diacare.15.10.1290
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发表时间：
1992-10-01
期刊：
影响因子：
16.2
通讯作者：
KAMADA, T
中科院分区：
文献类型：
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作者：
KAWAMORI, R;YAMASAKI, Y;KAMADA, T
研究设计和方法-对71名无高脂血症或高血压的非糖尿病受试者和295名糖尿病患者进行颈动脉超声高分辨率B型成像，以确定动脉壁的IMT。（IMT = [0.0087 X年龄]+0.3318）和糖尿病受试者（IMT = [0.0155 X年龄]+0.32450）。年龄的回归系数在糖尿病患者中显著高于非糖尿病患者。20 - 29岁糖尿病患者的IMT（平均值±标准差）显著大于20-29岁非糖尿病患者（0.73 ± 0.27对0.52 ± 0.07 mm，P < 0.01）。275例NIDDM患者的多变量回归分析表明，吸烟，高脂血症，糖尿病，高血压，和年龄的因素，确定颈动脉壁的厚度。结论-糖尿病，沿着年龄，高脂血症，吸烟，高血压，加重颈动脉粥样硬化。
OBJECTIVE - To quantitatively assess atherosclerosis of the carotid artery in subjects with and without diabetes.RESEARCH DESIGN AND METHODS - Ultrasound high resolution B-mode imaging of carotid arteries was conducted on 71 nondiabetic subjects without hyperlipidemia or hypertension and 295 diabetic patients to determine IMT of the arterial wall.RESULTS - IMT was linearly related with age in nondiabetic (IMT = [0.0087 X age] + 0.3318) and diabetic subjects (IMT = [0.0155 X age] + 0.32450). The regression coefficient for age was significantly greater in diabetic than nondiabetic subjects. IMT (mean +/- SD) of diabetic subjects aged 20 - 29 was significantly greater than that of nondiabetic subjects aged 20-29 (0.73 +/- 0.27 vs. 0.52 +/- 0.07 mm, P < 0.01). Multivariate regression analysis of 275 NIDDM patients indicated smoking, hyperlipidemia, duration of diabetes, hypertension, and age were factors determining thickness of the carotid arterial wall.CONCLUSIONS - Diabetes, along with age, hyperlipidemia, smoking, and hypertension, aggravates carotid atherosclerosis.