Age and case mix-standardised survival for all cancer patients in Europe 1999-2007: Results of EUROCARE-5, a population-based study
Age and case mix-standardised survival for all cancer patients in Europe 1999-2007: Results of EUROCARE-5, a population-based study
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DOI：
10.1016/j.ejca.2015.07.025
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发表时间：
2015-10-01
影响因子：
8.4
通讯作者：
Francisci, Silvia
中科院分区：
文献类型：
--
作者：
Baili, Paolo;Di Salvo, Francesca;Francisci, Silvia
背景：在评估卫生保健服务的整体表现时，经常使用癌症后的总体存活率。它主要由公众、政界人士和媒体使用，由于不同癌症、风险因素和治疗方式的不同组合，临床医生经常对其不屑一顾。在这里，我们给出了欧洲所有癌症合并后的生存细节，将其与经济变量相关联，以提出差异的原因。方法：我们计算了参与EUROCARE-5项目的29个国家的年龄和癌症地点病例组合标准化所有癌症合并相对生存率(ACRS)，使用完整和分期的方法，从87个基于人口的癌症登记中获得了超过750万例癌症病例的数据。结果：丹麦、英国(英国)和东欧国家的存活率低于邻国。在整个欧洲，五年的ACR一直在增加，在1999-2001年至2005-2007年期间，在过去存活率较低的国家实现了大幅增长。男性和女性的五年ACR与国内生产总值(GDP)和全国卫生总支出(TNEH)等宏观经济变量呈正相关(R2约为70%)。最近GDP和TNEH增幅较大的国家癌症存活率增幅较大。结论：ACRS用于比较欧洲所有癌症存活率，同时考虑到病例组合的地理差异性。ACRS上的EUROCARE-5数据证实了以前的EUROCARE发现。存活率似乎与宏观经济决定因素相关，特别是与对医疗保健系统的投资有关。(C)2015爱思唯尔有限公司。保留所有权利。
Background: Overall survival after cancer is frequently used when assessing a health care service's performance as a whole. It is mainly used by the public, politicians and the media, and is often dismissed by clinicians because of the heterogeneous mix of different cancers, risk factors and treatment modalities. Here we give survival details for all cancers combined in Europe, correlating it with economic variables to suggest reasons for differences.Methods: We computed age and cancer site case-mix standardised relative survival for all cancers combined (ACRS) for 29 countries participating in the EUROCARE-5 project with data on more than 7.5 million cancer cases from 87 population-based cancer registries, using complete and period approach.Results: Denmark, United Kingdom (UK) and Eastern European countries had lower survival than neighbouring countries. Five-year ACRS has been increasing throughout Europe, and substantial increases, between 1999-2001 and 2005-2007, have been achieved in countries where survival was lower in the past. Five-year ACRS for men and women are positively correlated with macro-economic variables like the Gross Domestic Product (GDP) and Total National Expenditure on Health (TNEH) (R 2 about 70%). Countries with recent larger increases in GDP and TNEH had greater increases in cancer survival.Conclusions: ACRS serves to compare all cancer survival in Europe taking account of the geographical variability in case-mixes. The EUROCARE-5 data on ACRS confirm previous EUROCARE findings. Survival appears to correlate with macro-economic determinants, particularly with investments in the health care system. (C) 2015 Elsevier Ltd. All rights reserved.