Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion
Activation of androgen receptor induces ID1 and promotes hepatocellular carcinoma cell migration and invasion
复制标题
雄激素受体激活诱导ID1促进肝癌细胞迁移和侵袭
DOI：
10.1016/j.molonc.2012.06.005
复制
发表时间：
2012-10-01
影响因子：
6.6
通讯作者：
Li, Chao
中科院分区：
文献类型：
--
作者：
Ao, Junping;Meng, Jiao;Li, Chao
雄激素受体（AR）活性与癌症的发生和进展有关。在肝细胞癌（HCC）中，AR有助于HCC的发病率，但AR在HCC细胞迁移和侵袭中的作用仍不清楚。在这项研究中，我们发现AR在一个具有高转移潜能的HCC细胞系亚群中高水平表达。使用AR的慢病毒过表达或小发夹RNA敲低以及其配体激活AR的实验表明，AR激活促进HCC细胞迁移和侵袭。我们还发现，AR激活增强了转移促进基因ID1的表达，这导致HCC细胞迁移和侵袭增加。AR拮抗剂能够阻断这一过程，表明AR阳性HCC中的AR激活可能作为潜在的干预策略而被治疗性抑制。(c)2012年欧洲生物化学学会联合会。Elsevier B.V.出版，保留所有权利。
Androgen receptor (AR) activity is associated with cancer development and progression. In hepatocellular carcinoma (HCC), AR contributes to HCC incidence, but the role of AR in HCC cell migration and invasion remains largely unknown. In this study, we found that AR was expressed at high levels in a subgroup of HCC cell lines with high metastatic potential. Experiments using lentiviral overexpression or small hairpin RNA knockdown of AR as well as activation of AR by its ligand indicated that AR activation promoted HCC cell migration and invasion. We also found that AR activation enhanced the expression of a metastasis-promoting gene, ID1, which led to increased HCC cell migration and invasion. An AR antagonist was able to block this process, suggesting that AR activation in AR-positive HCC may be therapeutically inhibited as a potential intervention strategy. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.