MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins
MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins
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MicroRNA-449a 通过调节口袋蛋白作为人类膀胱癌的肿瘤抑制因子。
DOI：
10.1016/j.canlet.2012.01.027
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发表时间：
2012-07-01
期刊：
影响因子：
9.7
通讯作者：
Xie, Li-Ping
中科院分区：
文献类型：
--
作者：
Chen, Hong;Lin, Yi-Wei;Xie, Li-Ping
在14例膀胱癌组织中检测到microRNA-449 a（miR-449 a）的频繁下调。miR-449 a的恢复抑制了T24和5637人膀胱癌细胞的细胞生长并诱导了G1期阻滞。CDK 6和CDC 25 a在miR-449 a处理后下调，导致口袋蛋白Rb和p130的功能积累。外源性miR-449 a抑制了124个肿瘤异种移植物的生长，并且在miR-449 a处理的肿瘤中核增殖抗原Ki-67下调。这些结果表明miR-449 a在人膀胱癌中的肿瘤抑制作用。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Frequent downregulation of microRNA-449a (miR-449a) was detected in 14 human bladder cancer tissues. The restoration of miR-449a inhibited cell growth and induced G1-phase arrest in T24 and 5637 human bladder cancer cells. CDK6 and CDC25a were downregulated after miR-449a treatment, resulting in the functional accumulation of the pocket proteins Rb and p130. The growth of 124 tumor xenografts was suppressed by exogenous miR-449a, and the nuclear proliferation antigen Ki-67 was downregulated in miR-449a-treated tumors. These results suggest a tumor-suppressive role for miR-449a in human bladder cancer. (C) 2012 Elsevier Ireland Ltd. All rights reserved.