ASTROCYTOMAS IN CHILDHOOD - A POPULATION-BASED STUDY
ASTROCYTOMAS IN CHILDHOOD - A POPULATION-BASED STUDY
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DOI：
10.1016/0090-3019(85)90162-4
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发表时间：
1985-01-01
影响因子：
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通讯作者：
FLANNERY, JT
中科院分区：
文献类型：
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作者：
DOHRMANN, GJ;FARWELL, JR;FLANNERY, JT
据报道，一项针对儿童星形细胞瘤的人群研究。基于人群的研究消除了转诊偏差和基于特定医疗中心或特定外科医生经验的系列偏差。 42 年间，诊断出 179 例此类病例。诊断时的平均年龄为 8.9 岁。超过1/2的星形细胞肿瘤位于小脑。 1965 年至 1970 年间，星形细胞瘤数量达到峰值。颅内星形细胞瘤儿童 6 个月时的累积生存概率。第 1 年、第 2 年和第 5 年分别为 0.824、0.752、0.732 和 0.667；到 10 年和 20 年，累积生存概率分别降至 0.607 和 0.538。脑干肿瘤的生存期最短，平均生存期为 19 个月。 Longer survivals were noted with tumors of the cerebral hemispheres: 0.779, 0.748, 0.678 and 0.628 at 1, 2, 5 and 10 yr, respectively.存活时间最长的是患有小脑星形细胞瘤的儿童：1 岁时，他们的生存概率为 0.837，20 岁时，生存概率为 0.675。
A population-based study of astrocytomas occurring in children is reported. A population-based study eliminates referral bias and the bias of a series based on the experience of a given medical center or a particular surgeon. In a 42-yr period, 179 such cases were diagnosed. The average age at diagnosis was 8.9 yr. Over 1/2 of the strocytic tumors were located in the cerebellum. A peak in the number of astrocytomas was noted between 1965 and 1970. Cumulative probability of survival of children with intracranial astrocytomas at 6 mo. and at 1, 2 and 5 yr was 0.824, 0.752, 0.732 and 0.667; by 10 yr and 20 yr the cumulative probability of survival had fallen to 0.607 and 0.538. The shortest survival was observed with brainstem tumors, with an average survival of 19 mo. Longer survivals were noted with tumors of the cerebral hemispheres: 0.779, 0.748, 0.678 and 0.628 at 1, 2, 5 and 10 yr, respectively. The longest survivals were in those children with cerebellar astrocytomas: at 1 yr they had an 0.837 probability of survival and at 20 yr, 0.675.