EPIDEMIOLOGIC-STUDIES ON HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN CHINA
EPIDEMIOLOGIC-STUDIES ON HEMORRHAGIC-FEVER WITH RENAL SYNDROME IN CHINA
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DOI：
10.1093/infdis/154.3.394
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发表时间：
1986-09-01
影响因子：
6.4
通讯作者：
GAO, SY
中科院分区：
文献类型：
--
作者：
CHEN, HX;QIU, FX;GAO, SY
中国有超过20个省报告了肾综合征出血热（HFRS）。近年来，报告的病例数量显著增加，1983年超过80 000例。1981年以前报告的所有病例都来自农村地区，并归因于姬鼠。1981年，首次报告了与家鼠有关的病例暴发。与黑线姬鼠相关的病例比与家鼠相关的病例更严重。 黑线姬鼠相关疾病流行区农村人群隐性感染率低于黑线姬鼠相关疾病流行区城市人群隐性感染率。发病后，IgG抗体水平迅速升高，一周后达到峰值，并持续长达25年。从疫区的16种啮齿类动物、2种索克斯鼠、猫和黄鼠狼的肺组织中发现了抗原。A. agrarius，Apodemus peninsulae，和R.褐家鼠分别是农村地区、森林地区和城市地区HFRS的主要宿主。
Hemorrhagic fever with renal syndrome (HFRS) has been reported from > 20 provinces in China. The number of reported cases has increased markedly in recent years and surpassed 80,000 human cases in 1983. All of the cases reported before 1981 were from rural areas and were attributed to Apodemus rats. In 1981, outbreaks of cases associated with house rats were first reported. Cases associated with Apodemus agrarius were more severe than those associated with the house rat Rattus norvegicus. The rate of inapparent infection in the rural population of areas endemic for Apodemus-associated disease was lower than that of Rattus-associated urban disease. After the onset of the disease, IgG antibody levels increase rapidly, peak after one week, and persist for as long as 25 years. Lung tissues from 16 species of rodent, from two species of sorex, and from cats and weasels in the epidemic areas have been found to carry antigen. A. agrarius, Apodemus peninsulae, and R. norvegicus serve as the main reservoirs of HFRS in rural areas, forest areas, and urban areas, respectively.