EARLY GROWTH AND ABDOMINAL FATNESS IN ADULT LIFE
EARLY GROWTH AND ABDOMINAL FATNESS IN ADULT LIFE
复制标题
DOI：
10.1136/jech.46.3.184
复制
发表时间：
1992-06-01
影响因子：
6.3
通讯作者：
SIMMONDS, SJ
中科院分区：
文献类型：
--
作者：
LAW, CM;BARKER, DJP;SIMMONDS, SJ
研究目的 - 目的是确定成年男性腹部肥胖是否与胎儿和婴儿期生长迟缓有关。 设计 - 这是一项跟踪研究，对象为 (1) 1920-30 年间出生的男性，其出生体重和一年时的体重由健康访视者记录； (2) 1935-43 年出生的男性，其出生时的尺寸经过详细测量。主要结果测量是腰围与臀围的比率。设置-赫特福德郡和英国普雷斯顿。受试者-受试者是 845 名出生于东赫特福德郡且仍居住在那里的男性；以及 239 名出生在普雷斯顿但仍居住在该市或该市附近的男性。 主要结果 - 考虑体重指数后，平均腰臀比随着出生体重的增加而下降，并随着胎盘重量与出生体重之比的增加而上升。这些趋势与妊娠持续时间无关，因此反映了胎儿生长迟缓。一年后，腰臀比也随着体重的增加而下降。所有这些趋势都与成人身高、饮酒量、吸烟、社会阶层和年龄无关。结论——腹部储存脂肪的倾向，已知会增加心血管疾病和糖尿病的风险，与肥胖无关，可能是对胎儿和婴儿期不利条件和生长障碍的持续反应。
Study objective-The aim was to determine whether abdominal fatness in adult men is associated with retarded growth in fetal life and infancy.Design-This was a follow up study of (1) men born during 1920-30 whose birthweights and weights at one year were recorded at the time by health visitors; and (2) men born during 1935-43 whose size at birth was measured in detail. The main outcome measure was the ratio of waist circumference to hip girth.Setting-Hertfordshire and Preston, England.Subjects-Subjects were 845 men born in east Hertfordshire who still live there; and 239 men born in Preston who still live in or close to the city.Main results-After allowing for body mass index, mean waist to hip ratio fell with increasing birthweight and rose as the ratio of placental weight to birthweight increased. These trends were independent of duration of gestation and therefore reflected retarded fetal growth. Waist to hip ratio also fell with increasing weight at one year. All these trends were independent of adult height, alcohol consumption, smoking, social class, and age.Conclusions-The tendency to store fat abdominally, which is known to increase the risk of cardiovascular disease and diabetes independently of obesity, may be a persisting response to adverse conditions and growth failure in fetal life and infancy.