Children's risk and resilience following a natural disaster: Genetic vulnerability, posttraumatic stress, and depression
Children's risk and resilience following a natural disaster: Genetic vulnerability, posttraumatic stress, and depression
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DOI：
10.1016/j.jad.2013.07.024
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发表时间：
2013-12-01
影响因子：
6.6
通讯作者：
Short, Mary A.
中科院分区：
文献类型：
--
作者：
La Greca, Annette M.;Lai, Betty S.;Short, Mary A.
目的：我们研究了儿童在自然灾害后的风险和复原力，评估了压力、社会支持和两个遗传标记的作用：5-羟色胺转运体基因的短等位基因(5-HTTLPR)和脑源性神经营养因子(BDNF)的MET等位基因。在高水平的飓风暴露或飓风相关应激源下，我们预计显示这些标记的儿童会比没有这些标记的儿童报告更严重的创伤后应激障碍(PTSD)和抑郁症状。方法：在飓风艾克8个月后，居住在德克萨斯州加尔维斯顿的116名儿童(男性=8.85岁，SD 89；54%女孩)提供唾液样本，完成了飓风暴露和压力、创伤后应激障碍和抑郁症状的测量；80人还完成了社会支持测量。结果：对于BDNF，分析揭示了几个环境交互作用的基因；压力越大，创伤后应激障碍和抑郁的症状越多，这种影响对Met等位基因儿童的影响更大。5-HTTLPR没有发现。压力源和社会支持也与儿童的创伤后应激障碍和抑郁症状有关。限制：研究结果应通过相对较小的样本进行调整，特别是在包括社会支持的分析中。结论：MET等位基因(BDNF)可能在儿童的灾难反应中发挥作用。进一步的研究应该考虑基因、压力源、支持和随着时间推移的心理结果之间复杂的相互作用。(C)2013爱思唯尔B.V.保留所有权利。
Objective: We examined children's risk and resilience following a natural disaster, evaluating the role of stress, social support, and two genetic markers: the short allele of the serotonin transporter gene (5-HTTLPR), and the met allele of the Brain-Derived Neurotrophic Factor (BDNF). Under high levels of hurricane exposure or hurricane-related stressors, we expected children displaying the markers would report greater symptoms of posttraumatic stress disorder (PTSD) and depression than children without these markers. Social support was explored as an additional moderating variable.Method: Eight months after Hurricane Ike, 116 children (M age=8.85 years, SD 89; 54% girls) residing in Galveston, Texas, provided saliva samples and completed measures of hurricane exposure and stress, and symptoms of PTSD and depression; 80 also completed a social support measure.Results: For BDNF, analyses revealed several Gene by Environment interactions; greater stress was related to more symptoms of PTSD and depression, and this effect was stronger for children with the met allele. No findings emerged for 5-HTTLPR. Stressors and social support also were associated with children's PTSD and depressive symptoms.Limitations: Findings should be tempered by the relatively small sample, especially for analysis that included social support.Conclusions: The met allele (BDNF) may play a role in children's disaster reactions. Further research should consider the complex interplay between genes, stressors, support, and psychological outcomes over time. (C) 2013 Elsevier B.V. All rights reserved.