Mortality of workers potentially exposed to organic and inorganic brominated chemicals, DBCP, TRIS, PBB, and DDT.
Mortality of workers potentially exposed to organic and inorganic brominated chemicals, DBCP, TRIS, PBB, and DDT.
复制标题
可能接触有机和无机溴化化学品、DBCP、TRIS、PBB 和 DDT 的工人的死亡率。
DOI：
10.1136/oem.41.1.15
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
G. Nagle
中科院分区：
文献类型：
--
作者：
O. Wong;W. Brocker;H. V. Davis;G. Nagle
对1935年至1976年间受雇的3579名白人男工进行了一项历史前瞻性死亡研究，他们可能接触的溴化物包括1，2-二溴-3-氯丙烷(DBCP)、三(2，3-二溴丙基)磷酸、多溴联苯(PBB)、各种有机和无机溴化物和滴滴涕。其中3384人(95%)的生命状况已确定为1976年12月31日：2806人(79%)仍活着，578人(16%)已死亡。获得死亡证明的死亡人数为541人(占全部死亡人数的94%)。将整个队列和几个子队列的死亡率与根据年龄和日历时间调整后的美国白人男性的死亡率进行了比较。比较统计量为常用的标准化死亡率(SMR)。没有历史的工业卫生数据，工人按工作区域或部门进行分类，以估计他们潜在的暴露。整个队列和几个亚组的总体死亡率明显低于预期。在整个队列中，在循环系统疾病、非恶性呼吸系统疾病和消化系统疾病中观察到显著的死亡率缺陷。另一方面，队列中的糖尿病死亡率显著升高。在可能接触Tris或DDT的员工中，没有检测到明显的总体或特定原因的死亡率超标。在可能接触DBCP的工人中，观察到由于循环系统疾病而导致的显著死亡率过高。在那些可能接触其他有机溴化物的人中，睾丸癌的死亡率明显高于预期。那些死于睾丸癌的人常见的潜在接触是甲基溴。由于缺乏准确的历史接触信息，而且许多工人可能接触到多种化学品，因此很难就观察到的过度死亡的原因得出明确的结论。
A historical prospective mortality study was conducted on 3579 white male workers employed between 1935 and 1976 with potential exposures to brominated compounds including 1,2-dibromo-3-chloropropane (DBCP), Tris (2,3-dibromopropyl) phosphate, polybrominated biphenyls (PBB), various organic and inorganic bromides, and DDT. The vital status as of 31 December 1976 was determined for 3384 (95%) of these workers: 2806 (79%) were still living and 578 (16%) had died. Death certificates were obtained for 541 deaths (94% of all deaths). The mortality experience of the entire cohort and several subcohorts was compared with that of United States white men adjusted for age and calendar time. The comparison statistic was the commonly used standardised mortality ratio (SMR). Historical industrial hygiene data were not available, and the workers were classified by their work areas or departments in order to estimate their potential exposures. Overall mortality for the entire cohort and several subgroups was significantly lower than expected. For the entire cohort, significant mortality deficits were observed in diseases of the circulatory system, non-malignant respiratory disease, and diseases of the digestive system. On the other hand, mortality from diabetes mellitus was significantly raised for the cohort. No significant overall or cause-specific mortality excess was detected among employees potentially exposed to either TRIS or DDT. A significant mortality excess due to diseases of the circulatory system was observed among workers potentially exposed to DBCP. Mortality from testicular cancer was significantly higher than expected among those potentially exposed to other organic bromides. The common potential exposure of those who had died of testicular cancer was methyl bromide. Owing to the lack of accurate historical exposure information and the fact that many workers were potentially exposed to a multitude of chemicals, it is difficult to draw definitive statements on the causations of the observed mortality excesses.