Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)
Time to pregnancy as a function of male and female serum concentrations of 2,2′4,4′5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE)
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DOI：
10.1093/humrep/dei397
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发表时间：
2006-03-01
影响因子：
6.1
通讯作者：
Hagmar, L
中科院分区：
文献类型：
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作者：
Axmon, A;Thulstrup, AM;Hagmar, L
背景：持久性有机氯污染物（POP）可影响动物和人类的雌性和雄性生殖系统。方法：从格陵兰、华沙和哈尔科夫的孕妇及其伴侣以及一群瑞典渔民的妻子那里收集了血液样本。对血样进行了2，2 '，4，4'，5，5 '-六氯联苯（CB-153）和1，1-二氯-2，2-双（对氯苯基）-乙烯（p，p'-DDE）分析。收集了参与者的生育能力信息，以妊娠时间（TTP）衡量。共有778名男性和1505名女性被纳入分析。结果：华沙，哈尔科夫和瑞典渔民的妻子的数据表明，无论是男性或女性接触持久性有机污染物对TTP没有影响。然而，在格陵兰的男性和女性中，CB-153和p，p '-DDE的血清浓度与TTP延长之间似乎存在关联。由于格陵兰人群中CB-153和p，p '-DDE之间的个体内相关性很强，因此无法确定风险是否与CB-153或p，p'-DDE相关，或者是两种化合物之间的相互作用。结论：本研究的总体结果创建了一个有点模糊的模式，但提供了一些支持的想法，饮食持久性有机污染物的暴露可能是有害的夫妇生育能力。
BACKGROUND: Persistent organochlorine pollutants (POP) may affect both the female and male reproductive system in animals as well as in humans. METHODS: Blood samples were collected from pregnant women and their partners from Greenland, Warsaw and Kharkiv, and from a cohort of Swedish fishermen's wives. Blood samples were analysed for 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE). Information on the participants' fertility, measured as time to pregnancy (TTP), was collected. In total, 778 men and 1505 women were included in the analyses. RESULTS: The data from Warsaw, Kharkiv and the Swedish fishermen's wives indicated no effect of either male or female exposure to POP on TTP. However, among men and women from Greenland, there seemed to be an association between serum concentrations of CB-153 and p,p'-DDE and prolonged TTP. Due to the strong intra-individual correlation between CB-153 and p,p'-DDE in the Greenlandic population, it was not possible to determine whether the risk was associated with CB-153 or p, p'-DDE or was an interaction between the two compounds. CONCLUSIONS: The overall results of the present study create a somewhat ambiguous pattern, but give some support to the idea that dietary POP exposure might be harmful for couple fertility.