Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey.
Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey.
复制标题
纳洛酮、纳曲酮和吗啡对松鼠猴的心血管作用。
DOI：
10.1016/0024-3205(83)90085-1
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发表时间：
1983
期刊：
影响因子：
6.1
通讯作者：
Byrd,LD
中科院分区：
文献类型：
--
作者：
Byrd,LD
心率（HR）和平均动脉血压（BP）记录从清醒的，椅子约束的松鼠猴手术准备长期留置动脉和静脉导管，以确定急性静脉注射两种阿片拮抗剂和激动剂的影响。纳洛酮（0.3-10.0 mg/kg）或纳洛酮（0.3-10.0 mg/kg）在注射后30分钟内对HR或BP几乎没有影响。吗啡（3.0-5.6 mg/kg）产生双相效应，包括HR最初降低，随后增加，以及BP升高，随后降低。较低的吗啡剂量在注射后100分钟内的影响较小。0.03mg/kg纳洛酮预处理可减弱吗啡对心率和血压的抑制作用，但增强吗啡引起的心率和血压升高。用0.3 mg/kg纳洛酮预处理防止了吗啡诱导的HR和BP降低，但HR和BP升高持续存在。在以前的行为研究中，吗啡与纳洛酮联合使用同样增加了松鼠猴的反应率。总之，这些数据表明纳洛酮的作用超出了吗啡作用的单纯药理学拮抗作用。
Heart rate (HR) and mean arterial blood pressure (BP) were recorded from conscious, chair-restrained squirrel monkeys surgically prepared with chronically indwelling arterial and venous catheters to determine the effects of acute intravenous injections of two opiate antagonists and an agonist. Naloxone (0.3–10.0 mg/kg) or naltrexone (0.3–10.0 mg/kg) had little effect on HR or BP during a 30-minute post-injection period. Morphine (3.0–5.6 mg/kg) produced biphasic effects comprising an initial decrease followed by an increase in HR, and an increase followed by a decrease in BP. Lower morphine doses had lesser effects during a 100-minute post-injection period. Pre-treatment with 0.03 mg/kg naloxone attenuated the depressive effect of morphine on HR and BP, but increases in HR and BP due to morphine were enhanced. Pretreatment with 0.3 mg/kg naloxone prevented morphine-induced decreases in HR and BP, yet increases in HR and BP persisted. In previous behavioral studies, morphine in combination with naloxone similarly increased rates of responding in the squirrel monkey. Together, these data suggest an effect of naloxone that goes beyond mere pharmacological antagonism of the effects of morphine.