Sexual dimorphism of niche architecture and regulation of the Caenorhabditis elegans germline stem cell pool
Sexual dimorphism of niche architecture and regulation of the Caenorhabditis elegans germline stem cell pool
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DOI：
10.1091/mbc.e19-03-0164
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发表时间：
2019-07-01
影响因子：
3.3
通讯作者：
Kimble, Judith
中科院分区：
文献类型：
--
作者：
Crittenden, Sarah L.;Lee, ChangHwan;Kimble, Judith
通过小生境信号维持干细胞是整个胚胎发育的共同主题。在秀丽隐杆线虫性腺中，生殖系干细胞（GSC）调节的大致轮廓对于两种性别是相同的：来自间充质远端尖端细胞龛的GLP-1/Notch信号传导维持两种性别的远端性腺中的GSC，并且通过两种关键的干细胞调节因子SYGL-1和LST-1来实现。然而，最近的生态位信号和GSC调控的分析集中在XX雌雄同体，一个基本上是女性的性别，使精子在幼虫和卵母细胞在成年人。在这里，我们专注于XO男性的GSC调节。先前报道的生态位结构的性别二态性表明，对生态位信号或GSC数量的分子反应也可能是性别不同的。值得注意的是，事实并非如此。这项工作扩展了我们对性二态生态位结构的理解，但也表明二态生态位驱动类似的分子反应，并在其干细胞库中维持类似数量的GSC。
Stem cell maintenance by niche signaling is a common theme across phylogeny. In the Caenorhabditis elegans gonad, the broad outlines of germline stem cell (GSC) regulation are the same for both sexes: GLP-1/Notch signaling from the mesenchymal distal tip cell niche maintains GSCs in the distal gonad of both sexes and does so via two key stem cell regulators, SYGL-1 and LST-1. Yet most recent analyses of niche signaling and GSC regulation have focused on XX hermaphrodites, an essentially female sex making sperm in larvae and oocytes in adults. Here we focus on GSC regulation in XO males. Sexual dimorphism of niche architecture, reported previously, suggested that the molecular responses to niche signaling or numbers of GSCs might also be sexually distinct. Remarkably, this is not the case. This work extends our understanding of the sexually dimorphic niche architecture, but also demonstrates that the dimorphic niches drive a similar molecular response and maintain a similar number of GSCs in their stem cell pools.