Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity.
Brown adipose tissue in humans is activated by elevated plasma catecholamines levels and is inversely related to central obesity.
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人类中的棕色脂肪组织被血浆儿茶酚胺水平升高激活，并且与中枢性肥胖成反比。
DOI：
10.1371/journal.pone.0021006
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Wang Q;Zhang M;Ning G;Gu W;Su T;Xu M;Li B;Wang W
最近的研究表明，成年人拥有活跃的棕色脂肪组织（BAT），这对于控制肥胖可能很重要。众所周知，β-肾上腺素受体-UCP1 系统在啮齿动物中调节 BAT，但其对成年人的影响仍有待证明。本研究旨在确定成年人儿茶酚胺水平升高是否可以独立刺激 BAT 活性，以及是否与肥胖相关。我们研究了 14 名嗜铬细胞瘤患者和 14 名正常受试者，他们在 2007 年至 2010 年期间进行了 18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描 (18F-FDG PET/CT) 和血浆总变肾上腺素 (TMN) 测量。 TMN水平升高的患者（A组：6/8和6.7±2.1 SUVmean·g/ml）的BAT检出率和平均BAT活性显着高于TMN浓度正常的患者（B组：0/6和0.4±0.04 SUVmean·g/ml）和正常受试者（C组：0/14和0.4±0.03 SUVmean·g/ml）。 BAT 活性与 TMN 水平呈正相关（R = 0.83，p<0.0001），与体重指数（R = −0.47，p = 0.010）、内脏脂肪面积（R = −0.39，p = 0.044）、内脏/总脂肪面积呈负相关脂肪面积（R = −0.52，p = 0.0043）和腰围（R = −0.43，p = 0.019）。稳健回归显示，TMN（R = 0.81，p<0.0001）和腰围（R = −0.009，p = 0.009）是BAT活动的两个独立预测因子。成年人的棕色脂肪组织活性可以通过升高的血浆 TMN 水平来激活，例如在嗜铬细胞瘤患者的情况下，并且与中枢性肥胖呈负相关。
Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in controlling obesity. It is known that ß-adrenoceptor-UCP1 system regulates BAT in rodent, but its influence in adult humans remains to be shown. The present study is to determine whether BAT activity can be independently stimulated by elevated catecholamines levels in adult human, and whether it is associated with their adiposity. We studied 14 patients with pheochromocytoma and 14 normal subjects who had performed both 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and plasma total metanephrine (TMN) measurements during 2007–2010. The BAT detection rate and the mean BAT activity were significantly higher in patients with elevated TMN levels (Group A: 6/8 and 6.7±2.1 SUVmean· g/ml) than patients with normal TMN concentrations (Group B: 0/6 and 0.4±0.04 SUVmean· g/ml) and normal subjects (Group C: 0/14 and 0.4±0.03 SUVmean·g/ml). BAT activities were positively correlated with TMN levels (R = 0.83, p<0.0001) and were inversely related to body mass index (R = −0.47, p = 0.010), visceral fat areas (R = −0.39, p = 0.044), visceral/total fat areas (R = −0.52, p = 0.0043) and waist circumferences (R = −0.43, p = 0.019). Robust regression revealed that TMN (R = 0.81, p<0.0001) and waist circumferences (R = −0.009, p = 0.009) were the two independent predictors of BAT activities. Brown adipose tissue activity in adult human can be activated by elevated plasma TMN levels, such as in the case of patients with pheochromocytoma, and is negatively associated with central adiposity.