Pinning down viral proteins: a new prototype for virus-host cell interaction
Pinning down viral proteins: a new prototype for virus-host cell interaction
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DOI：
10.3389/fmicb.2010.00107
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发表时间：
2010-01-01
影响因子：
5.2
通讯作者：
Ryo, Akihide
中科院分区：
文献类型：
--
作者：
Kojima, Yoshitsugu;Ryo, Akihide
Pin 1是一种特异性催化其底物蛋白中磷酸化丝氨酸/苏氨酸-脯氨酸（pSer/Thr-Pro）基序顺反异构化的酶。最近的研究表明，几种病毒蛋白的稳定性由宿主因子Pin 1的磷酸化依赖性脯氨酰异构化调节。Pin 1目前被定位为病毒和宿主细胞之间分子串扰的重要调节剂，并可能成为抗病毒治疗的独特靶点。Pin 1的这种新型翻译后修饰可能参与其他病毒蛋白的调节。
Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.