Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines
Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines
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DOI：
10.1086/430929
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发表时间：
2005-08-01
影响因子：
6.4
通讯作者：
Friedman, JF
中科院分区：
文献类型：
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作者：
Coutinho, HM;McGarvey, ST;Friedman, JF
在对菲律宾Leyte的641名7-30岁日本血吸虫感染者的横断面研究中，我们通过超声确定了肝纤维化（HF）的等级，并使用人体测量和血红蛋白水平来评估营养状况。血清白细胞介素(IL)-1、IL- 6、IL- 10水平；肿瘤坏死因子- α；可溶性tnf - α受体I；和c反应蛋白（CRP），以检查这些炎症标志物与HF分级之间的关系。8.9%的队列中存在HF；大多数病例为轻度（I级），重度（II级或III级）病例仅发生在男性个体中。与非HF患者相比，重度HF患者（以及轻度HF患者）的身体质量指数（BMI）和BMI z-score明显较低，贫血患病率较高，CRP水平较高，且更容易产生IL- 6；此外，重度HF患者IL- 1水平明显高于无HF或轻度HF患者。这些发现表明，即使是轻微的心衰也与营养发病率有关，并强调了早期识别和治疗的重要性。此外，我们的数据与假设一致，即通过系统性地增加促炎细胞因子IL- 1和IL- 6的水平，HF导致营养不良和贫血。
In a cross-sectional study of 641 Schistosoma japonicum-infected individuals in Leyte, Philippines, who were 7-30 years old, we determined the grade of hepatic fibrosis (HF) by ultrasound and used anthropometric measurements and hemoglobin levels to assess nutritional status. Serum levels of interleukin (IL)-1, IL- 6, and IL10; tumor-necrosis factor (TNF)-alpha; soluble TNF-alpha receptor I; and C-reactive protein (CRP) were measured to examine the association between these markers of inflammation and HF grade. HF was present in 8.9% of the cohort; the majority of cases were mild ( grade I), and severe (grade II or grade III) cases occurred only in male individuals. Compared with individuals without HF, those with severe HF - and, to a lesser degree, those with mild HF - had a significantly lower body-mass index (BMI) and BMI z-score, a higher prevalence of anemia, and a higher level of CRP and were more likely to produce IL- 6; furthermore, those with severe HF had a significantly higher level of IL- 1, compared with those either without HF or with mild HF. These findings suggest that even mild HF is associated with nutritional morbidity and underscore the importance of early recognition and treatment. In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL- 1 and IL- 6, HF causes undernutrition and anemia.