Formulation, Characterization and Physicochemical Evaluation of Potassium Citrate Effervescent Tablets
Formulation, Characterization and Physicochemical Evaluation of Potassium Citrate Effervescent Tablets
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DOI：
10.5681/apb.2013.036
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发表时间：
2013-06-01
影响因子：
3.6
通讯作者：
Fattahi, Fatemeh
中科院分区：
文献类型：
--
作者：
Aslani, Abolfazl;Fattahi, Fatemeh
目的：本研究的目的是设计并制备柠檬酸钾缓释片，用于减少肾结石患者的草酸钙和尿酸盐肾结石。方法：以枸橼酸钾和苦参碱为原料，按不同浓度配制成13种制剂。研究了粉末和颗粒的流动性。然后采用直接压片法、熔融法和湿法制粒法制备片剂。评价制备的片剂的硬度、脆碎度、崩解时间、pH值、含量均匀度。为了改善制剂的口味，使用不同的调味剂，然后由30名志愿者采用拉丁方法进行小组试验。结果：直接压片法和熔融法制备的制剂流动性好，但硬度低。湿法制粒改善了流动性和其他物理化学性质，如可接受的硬度，
Purpose: The aim of this study was to design and formulation of potassium citrate effervescent tablet for reduction of calcium oxalate and urate kidney stones in patients suffering from kidney stones. Methods: In this study, 13 formulations were prepared from potassium citrate and effervescent base in different concentration. The flowability of powders and granules was studied. Then effervescent tablets were prepared by direct compression, fusion and wet granulation methods. The prepared tablets were evaluated for hardness, friability, effervescent time, pH, content uniformity. To amend taste of formulations, different flavoring agents were used and then panel test was done by using Latin Square method by 30 volunteers. Results: Formulations obtained from direct compression and fusion methods had good flow but low hardness. Wet granulation improves flowability and other physicochemical properties such as acceptable hardness, effervescence time