Na+ channel distribution and inactivation properties of human type 1 and 2 muscle fibers.
Na+ channel distribution and inactivation properties of human type 1 and 2 muscle fibers.
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人 1 型和 2 型肌纤维的 Na 通道分布和失活特性。
DOI：
10.1111/j.1749-6632.1993.tb22923.x
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发表时间：
1993
影响因子：
5.2
通讯作者：
Whittlesey,D
中科院分区：
文献类型：
--
作者：
Ruff,RL;Whittlesey,D
大鼠和兔骨骼肌纤维上的Na‘通道有两个不同的失活过程，具有不同的动力学和电压依赖性。’-~快速失活足以终止动作电位。‘慢失活太慢而不影响动作电位终止。然而，慢失活比快失活工作在更负的电位下，因此通道在闭合和慢失活状态之间的分布可以调节可兴奋的Na‘通道的数量。3在大鼠快抽动肌纤维中，紧邻终板的I_1比远离终板的高约5~10倍，随着远离终板的距离，I_i迅速下降，在距离终板100~200 PM时达到背景水平。
Na'channels on rat and rabbit skeletal muscle fibers have two inactivation processes with different kinetics and voltage dependen~ e.'-~ Fast inactivation is sufficiently rapid to terminate the action potential.'Slow inactivation is too slow to affect action potential termination. Slow inactivation, however, operates at more negative potentials than fast inactivation, so that the distribution of channels between closed and slow inactivated states may regulate the number of excitable Na'channels. 3In rat fast twitch muscle fibers, I,, is about 5-10-fold higher immediately adjacent to the end-plate than at regions away from the end-plate.'I,, declines rapidly with distance away from the end-plate, reaching the background level at 100-200 pm from the end-plate.