Effect of sodium thiosulfate on cis-dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia.
Effect of sodium thiosulfate on cis-dichlorodiammineplatinum(II) toxicity and antitumor activity in L1210 leukemia.
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硫代硫酸钠对 L1210 白血病顺式二氯二氨铂 (II) 毒性和抗肿瘤活性的影响。
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发表时间：
1980
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影响因子：
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通讯作者：
R. Taetle
中科院分区：
文献类型：
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作者：
Howell Sb;R. Taetle
同时给药硫代硫酸钠以剂量相关的方式降低了顺式二氯二胺铂（DDP）对小鼠的毒性。硫代硫酸钠保护小鼠免受致死剂量的DDP （20 mg/kg）的伤害，并减轻DDP引起的体重下降。在DDP前1小时或后1/2小时内注射硫代硫酸钠（800 mg/kg）阻断肾毒性，通过BUN升高、肾重量增加和髓质出血来测量。在培养中，硫代硫酸钠显著降低了DDP对小鼠菌落形成单位的毒性。同时注射硫代硫酸钠可部分降低DDP的抗肿瘤活性。DDP的治疗剂量范围扩大，但L1210白血病小鼠的最大寿命增加减少了40%。硫代硫酸钠提供了对人体区域施用DDP的细胞毒性的全身保护的可能性。
Concurrent administration of sodium thiosulfate reduced the toxicity of cis-dichlorodiammineplatinum(II) (DDP) in a dose-related manner in mice. Sodium thiosulfate protected mice against an otherwise lethal dose of DDP (20 mg/kg), and reduced DDP-induced weight loss. Sodium thiosulfate (800 mg/kg) injected within 1 hour before or 1/2 hour after DDP blocked nephrotoxicity as measured by a rise in BUN, an increase in kidney weight, and medullary hemorrhage. In culture, sodium thiosulfate markedly reduced the toxicity of DDP to mouse colony-forming units. Concurrent injection of sodium thiosulfate partially reduced the antitumor activity of DDP. The therapeutic dose range of DDP was expanded, but the maximum increase in lifespan of mice bearing L1210 leukemia was reduced by 40%. Sodium thiosulfate offers the possibility of systemic protection against the cytotoxicity of regionally administered DDP in man.