Mechanisms of sensorineural cell damage, death and survival in the cochlea.
Mechanisms of sensorineural cell damage, death and survival in the cochlea.
复制标题
耳蜗中感觉神经细胞损伤、死亡和存活的机制。
DOI：
10.3389/fnagi.2015.00058
复制
发表时间：
2015
影响因子：
4.8
通讯作者：
Ryan AF
中科院分区：
文献类型：
--
作者：
Wong AC;Ryan AF
大多数获得性听力损失（包括老年性耳聋）是由耳蜗感音神经组织的不可逆损伤引起的。本文回顾了导致耳蜗感觉神经损伤的细胞内机制，以及可以提供内源性保护和组织救援的生存信号通路。这些数据主要是在与年龄没有直接关系的听力损失中产生的。然而，有证据表明类似的机制在老年性耳聋中起作用。此外，其他原因造成的损害累积可能会导致年龄相关性听力损失（ARHL）。还讨论了平衡相反但相互关联的细胞损伤和生存途径的潜在治疗干预措施，例如抗氧化剂、抗凋亡剂和促炎细胞因子抑制剂。
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well as the survival signaling pathways that can provide endogenous protection and tissue rescue. These data have primarily been generated in hearing loss not directly related to age. However, there is evidence that similar mechanisms operate in presbycusis. Moreover, accumulation of damage from other causes can contribute to age-related hearing loss (ARHL). Potential therapeutic interventions to balance opposing but interconnected cell damage and survival pathways, such as antioxidants, anti-apoptotics, and pro-inflammatory cytokine inhibitors, are also discussed.