Anticancer therapy and lung injury: molecular mechanisms.
Anticancer therapy and lung injury: molecular mechanisms.
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DOI：
10.1080/14737140.2018.1500180
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发表时间：
2018-10
影响因子：
3.3
通讯作者：
Ghebre YT
中科院分区：
文献类型：
--
作者：
Li L;Mok H;Jhaveri P;Bonnen MD;Sikora AG;Eissa NT;Komaki RU;Ghebre YT
化疗和放疗是治疗不可手术的癌症的两种主流策略。血液或实体肿瘤恶性肿瘤患者可从化疗药物和/或递送至恶性肿瘤部位的电离辐射中获益。然而，相当多的不良反应，包括肺部炎症和纤维化，与使用这些治疗方式。随着我们迈向精准健康时代，我们不得不了解放化疗诱导的病理性肺重塑的分子基础，并制定有效的治疗策略，以减轻癌症患者慢性肺部疾病（即纤维化）的发展。该综述讨论了据报道诱导或与急性和/或慢性肺损伤相关的化疗药物。有必要从分子水平上了解化疗药物如何诱导呼吸毒性或与呼吸毒性相关，以及这些特征是否与其抗肿瘤作用内在相关或是附带的。一旦这些机制被确定和/或充分表征，它们可能能够指导疾病管理决策，包括针对不良反应的有效干预策略。与此同时，放射肿瘤学家应谨慎的剂量辐射输送到肺部，照射的肺体积，并同时使用化疗药物。
Chemotherapy and radiation therapy are two mainstream strategies applied in the treatment of cancer that is not operable. Patients with hematological or solid tumor malignancies substantially benefit from chemotherapeutic drugs and/or ionizing radiation delivered to the site of malignancy. However, considerable adverse effects, including lung inflammation and fibrosis, are associated with the use of these treatment modalities. As we move towards the era of precision health, we are compelled to understand the molecular basis of chemoradiation-induced pathological lung remodeling and to develop effective treatment strategies that mitigate the development of chronic lung disease (i.e. fibrosis) in cancer patients. The review discusses chemotherapeutic agents that are reported to induce or associate with acute and/or chronic lung injury. There is a need to molecularly understand how chemotherapeutic drugs induce or associate with respiratory toxicities and whether such characteristics are inherently related to their anti-tumor effect or are collateral. Once such mechanisms have been identified and/or fully characterized, they may be able to guide disease-management decisions including effective intervention strategies for the adverse effects. In the meantime, radiation oncologists should be judicious on the dose of radiation delivered to the lungs, the volume of lung irradiated, and concurrent use of chemotherapeutic drugs.
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影响因子：
51.1
作者：
Bradley, Jeffrey D.;Paulus, Rebecca;Komaki, Ritsuko;Masters, Gregory;Blumenschein, George;Schild, Steven;Bogart, Jeffrey;Hu, Chen;Forster, Kenneth;Magliocco, Anthony;Kavadi, Vivek;Garces, Yolanda I.;Narayan, Samir;Iyengar, Puneeth;Robinson, Cliff;Wynn, Raymond B.;Koprowski, Christopher;Meng, Joanne;Beitler, Jonathan;Gaur, Rakesh;Curran, Walter, Jr.;Choy, Hak
通讯作者：
Choy, Hak
影响因子：
4.3
作者：
Cao, TM;Negrin, RS;Hu, WW
通讯作者：
Hu, WW
影响因子：
4.8
作者：
Alessandrino, EP;Bernasconi, P;Bernasconi, C
通讯作者：
Bernasconi, C
影响因子：
8.4
作者：
Duran, I.;Siu, L. L.;Niroumand, M.
通讯作者：
Niroumand, M.
影响因子：
24.3
作者：
Abadie, Y;Bregeon, F;Delclaux, C
通讯作者：
Delclaux, C