Type B hepatitis: virology, serology and clinical course.
Type B hepatitis: virology, serology and clinical course.
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DOI：
10.1055/s-2008-1063925
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发表时间：
1981-02-01
影响因子：
4.2
通讯作者：
Hoofnagle, J H
中科院分区：
文献类型：
--
作者：
Hoofnagle, J H
B型肝炎病毒是一种42纳米（nm）的双壳DNA病毒，具有独特的抗原结构和DNA [38]。这种病毒具有高度的物种特异性，只感染人类和少数高等猿类。它还没有在细胞培养中成功生长。我们对B型肝炎病毒的了解，主要是由于对这种病毒的一种特异性血清学标志物--澳大利亚抗原的鉴定。1965年由Blumberg、Alter和Visnich发现[8]，澳大利亚抗原最初被认为是一种遗传性血清脂蛋白。几年后，该抗原与病毒性肝炎相关[9]，然后特异性地与B型肝炎相关[23，34]。从那时起，澳大利亚抗原已被证明是B型肝炎病毒的包膜或表面抗原。它现在被称为B型肝炎表面抗原（表1）。
The hepatitis B virus is a 42 nanometer (nm) double-shelled DNA virus with a unique antigenic structure and DNA [38]. The virus is highly speciesspecific, infecting only man and a few higher apes. It has yet to be successfully grown in cell culture. What is known about the hepatitis B virus has arisen largely out of the identification of a specific, serologic marker of this virus—the Australia antigen. Discovered in 1965 by Blumberg, Alter and Visnich [8], the Australia antigen was first thought to be a genetically inherited serum lipoprotein. Several years later, this antigen was linked to viral hepatitis [9] and then specifically to type B hepatitis [23, 34]. Since then, the Australia antigen has been shown to be the envelope or surface antigen of the hepatitis B virus. It is now known as the hepatitis B surface antigen (Table 1).