Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations
Effects of Vitamin D Supplementation on General and Central Obesity: Results from 20 Randomized Controlled Trials Involving Apparently Healthy Populations
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DOI：
10.1159/000507418
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发表时间：
2020-10-01
影响因子：
3.9
通讯作者：
Wang, Yan
中科院分区：
文献类型：
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作者：
Duan, Leizhen;Han, Ling;Wang, Yan
背景：肥胖流行的同时，维生素 D 缺乏症 (VDD) 的患病率也很高。越来越多的流行病学证据表明维生素 D 水平低与肥胖事件有关。此外，观察性研究还表明，肥胖可能会增加 VDD 的风险。然而，目前还没有足够的知识来了解两者之间是否存在因果关系。此外，补充维生素 D 对肥胖指数的影响表现出不一致的结果。目的：本荟萃分析旨在评估补充维生素 D 是否改变表面健康人群的全身肥胖指数和中心性肥胖指数。方法：使用 Pubmed、Embase、Web of Knowledge 和中国国家知识基础设施数据库对相关随机对照试验 (RCT) 进行系统检索。汇总加权平均差 (WMD) 和 95% 置信区间 (CI) 用于评估体重指数 (BMI)、腰围 (WC)、腰臀比 (WHR) 和 25-羟基维生素 D (25[OH]D) 相对于基线的变化。 结果：20 项随机对照试验涉及 3,153 名参与者，报告 BMI、WC、WHR 或 25(OH)D 符合纳入标准。与安慰剂相比，补充维生素 D 没有显着降低 BMI（WMD = -0.09 kg/m(2)，95% CI -0.19 至 0.01，p= 0.08）、腰围（WMD = -0.71 cm，95% CI -1.58 至 0.16，p= 0.112）或 WHR（WMD = 0.00，95% CI） -0.01 至 0.01，p= 0.749）。然而，在亚洲地区的女性亚组研究中，干预持续时间>=6个月，BMI和WC出现有益且显着的降低（所有p<0.026）。另一方面，汇总结果显示，维生素 D 干预后，血清 25(OH)D 水平显着升高（WMD = 13.20 ng/mL，95% CI 9.83-16.58，p < 0.001）。我们的研究未发现发表偏倚。结论：总体而言，补充维生素 D 对健康成人的 BMI、WC 或 WHR 没有显着影响。
Background:The obesity pandemic has been paralleled by a high prevalence of vitamin D deficiency (VDD). There is growing epidemiological evidence linking low vitamin D status with obesity events. In addition, observational studies also show that obesity may increase the risk of VDD. However, there is insufficient knowledge to understand whether there is a causality between the two. Moreover, the impact of vitamin D supplementation on obesity indices has shown inconsistent outcomes.Objective:This meta-analysis aimed to assess whether vitamin D supplementation modified general and central obesity indices in apparently healthy populations.Methods:A systematic retrieval of relevant randomized controlled trials (RCTs) was undertaken using Pubmed, Embase, Web of Knowledge and Chinese National Knowledge Infrastructure databases. The pooled weighted mean difference (WMD) and 95% confidence intervals (CI) were used to assess the changes in body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR) and 25-hydroxyvitamin D (25[OH]D) from baseline.Results:Twenty RCTs involving 3,153 participants reporting either BMI, WC, WHR or 25(OH)D met the inclusion criteria. When compared with placebo, vitamin D supplementation had no significant decreases in BMI (WMD = -0.09 kg/m(2), 95% CI -0.19 to 0.01,p= 0.08), WC (WMD = -0.71 cm, 95% CI -1.58 to 0.16,p= 0.112) or WHR (WMD = 0.00, 95% CI -0.01 to 0.01,p= 0.749). However, in the subgroups of females, Asia region studies and intervention duration >= 6 months, a beneficial and significant reduction in BMI and WC was noted (allp< 0.026). On the other hand, pooled results showed that there was a significant increase in serum 25(OH)D levels (WMD = 13.20 ng/mL, 95% CI 9.83-16.58,p< 0.001) after vitamin D intervention. No publication bias was found in our study.Conclusions:Overall, supplementation with vitamin D produced no significant effect on the BMI, WC or WHR of healthy adults.