VOLUMETRIC INTENSITY-MODULATED ARC THERAPY VS. CONVENTIONAL IMRT IN HEAD-AND-NECK CANCER: A COMPARATIVE PLANNING AND DOSIMETRIC STUDY
VOLUMETRIC INTENSITY-MODULATED ARC THERAPY VS. CONVENTIONAL IMRT IN HEAD-AND-NECK CANCER: A COMPARATIVE PLANNING AND DOSIMETRIC STUDY
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DOI：
10.1016/j.ijrobp.2008.12.033
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发表时间：
2009-05-01
影响因子：
7
通讯作者：
Senan, Suresh
中科院分区：
文献类型：
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作者：
Verbakel, Wilko F. A. R.;Cuijpers, Johan P.;Senan, Suresh
目的：体积调强弧形治疗（RA）允许快速输送高度适形的剂量分布。在这项研究中，将RA的计划和剂量测定与头颈部癌症患者的传统调强放射治疗（IMRT）计划进行了比较。材料和方法：对12名完成了鼻、口和下咽部晚期肿瘤调强放射治疗（IMRT）的患者进行计算机断层扫描。使用RA使用一个或两个弧线重新计划。比较了IMRT和RA计划的计划靶区（PTV）和危及器官（OAR）的计算剂量。单弧（n = 8）和双弧（n = 4）计划的剂量分布进行了验证，在三至五个冠状面使用质量保证phantom.Results：RA计划允许平均减少监测单位（MU）的数量近60%，相对于7个字段滑动窗口IMRT计划。RA计划实现了与IMRT相似的所有OAR保留。与单弧计划（2.0戈伊）和IMRT（1.7戈伊）相比，双弧RA提供了最佳的PTV剂量均匀性，PTV剂量的标准差（1.4戈伊）较低。X线片测量结果与计算剂量符合良好，平均γ值为0.30（双弧），γ值大于1的X线片面积为0.82%。结论：RA是一种快速、安全、准确的技术，使用的MU低于常规IMRT。双弧计划提供了至少相似的保留OAR和更好的PTV剂量均匀性比单弧或IMRT。(C)2009爱思唯尔公司
Purpose: Volumetric intensity-modulated arc therapy (RA) allows for rapid delivery of highly conformal dose distributions. In this study, planning and dosimetry of RA were compared with conventional intensity-modulated radiation therapy (IMRT) plans of head-and-neck cancer patients.Materials and Methods: Computed tomography scans of 12 patients who had completed IMRT for advanced tumors of the naso-, oro-and hypopharynx were replanned using RA using either one or two arcs. Calculated doses to planning target volume (PTV) and organs at risk (OAR) were compared between IMRT and RA plans. Dose distributions for single are (n = 8) and double arc (n = 4) plans were verified using film dosimetry in three to five coronal planes using a quality assurance phantom.Results: RA plans allowed for a mean reduction in number of monitor units (MU) by nearly 60%, relative to seven field sliding window IMRT plans. RA plans achieved similar sparing of all OAR as IMRT. Double arc RA provided the best dose homogeneity to PTV with a lower standard deviation of PTV dose (1.4 Gy), vs. single arc plans (2.0 Gy) and IMRT (1.7 Gy). Film measurements showed good correspondence with calculated doses; the mean gamma value was 0.30 (double arc) and area of the film with a gamma exceeding 1 was 0.82%.Conclusions: RA is a fast, safe, and accurate technique that uses lower MUs than conventional IMRT. Double arc plans provided at least similar sparing of OAR and better PTV dose homogeneity than single are or IMRT. (C) 2009 Elsevier Inc.